Effects of Weight Loss and Long-Term Weight Maintenance With Diets Varying in Protein and Glycemic Index on Cardiovascular Risk Factors: The Diet, Obesity, and Genes (DiOGenes) Study: A Randomized, Controlled Trial

We sought to separately examine the effects of either weight loss or diets varying in protein content and glycemic index without further changes in body weight on cardiovascular risk factors within the Diet, Obesity, and Genes study (DiOGenes). DiOGenes is a pan-European controlled dietary intervent...

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Published in:Circulation (New York, N.Y.) N.Y.), 2011-12, Vol.124 (25), p.2829-2838
Main Authors: GÖGEBAKAN, Ozlem, KOHL, Angela, HOLST, Claus, SARIS, Wim H. M, ASTRUP, Arne, PFEIFFER, Andreas F. H, OSTERHOFF, Martin A, VAN BAAK, Marleen A, JEBB, Susan A, PAPADAKI, Angeliki, MARTINEZ, J. Alfredo, HANDJIEVA-DARLENSKA, Teodora, HLAVATY, Petr, WEICKERT, Martin O
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure - physiology
Blood. Blood coagulation. Reticuloendothelial system
Body Mass Index
C-Reactive Protein - metabolism
Cardiology. Vascular system
Cardiovascular Diseases - diet therapy
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - genetics
Cardiovascular Diseases - prevention & control
Comorbidity
Diet, Protein-Restricted - methods
Diet, Reducing - methods
Dietary Carbohydrates - administration & dosage
Dietary Proteins - administration & dosage
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Glycemic Index - physiology
Humans
Lipids - blood
Male
Medical sciences
Obesity - diet therapy
Obesity - epidemiology
Obesity - genetics
Pharmacology. Drug treatments
Risk Factors
Weight Loss - physiology
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Summary:We sought to separately examine the effects of either weight loss or diets varying in protein content and glycemic index without further changes in body weight on cardiovascular risk factors within the Diet, Obesity, and Genes study (DiOGenes). DiOGenes is a pan-European controlled dietary intervention study in 932 overweight adults who first lost body weight on an 8-week low-calorie diet and were then randomized to 1 of 5 ad libitum diets for 26 weeks. The diets were either high or low protein or high or low glycemic index in 4 combinations or control. Weight loss (-11.23 kg; 95% confidence interval, -11.54 to -10.92; P
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.111.033274