Is zinc-α2-glycoprotein a cardiovascular protective factor for patients undergoing hemodialysis?

Zinc-α2-glycoprotein (ZAG) is a lipid mobilizing factor. Its anti-inflammatory action and expression pattern suggest that ZAG could act by protecting against the obesity-associated disorders. In hemodialysis (HD) patients, ZAG levels were described to be elevated but its effects on markers of inflam...

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Bibliographic Details
Published in:Clinica chimica acta 2012-03, Vol.413 (5-6), p.616-619
Main Authors: Leal, Viviane O., Lobo, Julie C., Stockler-Pinto, Milena B., Farage, Najla E., Abdalla, Dulcinéia S.P., Leite Junior, Maurilo, Mafra, Denise
Format: Article
Language:English
Subjects:
Adipokine
Atherosclerosis
Cardiovascular Diseases - blood
Hemodialysis
Humans
Inflammation
Renal Dialysis
Seminal Plasma Proteins - blood
Zinc-α2-glycoprotein
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Summary:Zinc-α2-glycoprotein (ZAG) is a lipid mobilizing factor. Its anti-inflammatory action and expression pattern suggest that ZAG could act by protecting against the obesity-associated disorders. In hemodialysis (HD) patients, ZAG levels were described to be elevated but its effects on markers of inflammation and LDL oxidation are still unclear. We investigated the relationship between ZAG and markers of systemic inflammation and LDL atherogenic modification profile in HD patients. Forty-three patients regularly on HD were studied and compared to 20 healthy subjects. Plasma ZAG, adiponectin, electronegative LDL [LDL(−)], an atherosclerotic negatively charged LDL subfraction, and anti-LDL(−) autoantibodies levels were measured by ELISA. Markers of inflammation and atherogenic cell recruitment (TNF-α, interleukin-6, VCAM-1, ICAM-1, MCP-1 and PAI-1) were also determined. Inflammatory markers and atherogenic cell recruitment were higher in HD patients when compared to healthy subjects. ZAG levels were also higher in HD patients (151.5±50.1mg/l vs 54.6±23.0mg/l; p
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2011.12.002