The impact of dietary induced hyperparathyroidism on healthy and diseased periodontia: an experimental study in rats

Background and Objective Nutrition may be a potential modifying factor in periodontal conditions. The present study investigated this phenomenon for dietary induced hyperparathyroidism (dHPT) by revealing the histopathological and histomorphometrical profiles of healthy and diseased periodontia in d...

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Published in:Journal of clinical periodontology 2012-03, Vol.39 (3), p.264-271
Main Authors: LÜTFIOGLU, Müge, SAKALLIOGLU, Umur, ESER SAKALLIOGLU, Elif, BARIS, Sancar, GÜRGÖR, Pmar
Format: Article
Language:English
Subjects:
Alveolar Bone Loss - etiology
Animals
Biological and medical sciences
Calcium, Dietary - pharmacology
Cell Count
Chronic Periodontitis - etiology
Cytokines - metabolism
Dentistry
dietary induced hyperparathyroidism
Endocrinopathies
Endotoxins
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Gingivitis - etiology
host modifying factors
Hyperparathyroidism, Secondary - chemically induced
Hyperparathyroidism, Secondary - complications
Male
Medical sciences
Non tumoral diseases
Non tumoral diseases. Target tissue resistance. Benign neoplasms
nutrition
Osteoclasts - physiology
Otorhinolaryngology. Stomatology
Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases)
periodontal disease
Rats
Rats, Sprague-Dawley
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Summary:Background and Objective Nutrition may be a potential modifying factor in periodontal conditions. The present study investigated this phenomenon for dietary induced hyperparathyroidism (dHPT) by revealing the histopathological and histomorphometrical profiles of healthy and diseased periodontia in dHPT. Methods Dietary induced hyperparathyroidism was induced in 12 rats by dietary calcium/phosphorous imbalance and 12 rats were fed standard diet (SD). Periodontitis was induced on the right mandibular molar teeth (mmt) of these rats by injecting an endotoxin + saline solution whereas injecting pure saline to the left mmt. Thus, four study groups were created: dHPT + saline (group 1), dHPT + endotoxin (group 2), SD + endotoxin (group 3) and SD + saline (group 4). Histological sections were obtained from the second mmt and examined using light microscope. Results Group 1 demonstrated inflammatory and degenerative alterations in periodontium without pocket formation. Periodontitis was evident in groups 2 and 3. Group 2 revealed the highest amounts of gingival inflammatory cell and vessel counts (group 2 > group 3 > group 1 > group 4), attachment and bone losses (group 2 > group 3 > groups 1 > group 4) and osteoclast count (group 2 > group 3 > group 1 > group 4) (p 
ISSN:0303-6979
1600-051X
DOI:10.1111/j.1600-051X.2011.01814.x