Discovery of Novel Stem Cell Mobilizers That Target the CXCR4 Receptor

Going mobile: Based on screening hit 1, a novel class of polyamine compounds, as represented by compound 8, were identified as potent and selective CXCR4 antagonists. CXCR4‐targeted molecules, as demonstrated by the marketed AMD3100 and 8, are able to mobilize stem cells from bone marrow effectively...

Full description

Saved in:
Bibliographic Details
Published in:ChemMedChem 2012-02, Vol.7 (2), p.209-212
Main Authors: Wu, Chien-Huang, Chang, Chun-Ping, Song, Jen-Shin, Jan, Jiing-Jyh, Chou, Ming-Chen, Wu, Szu-Huei, Yeh, Kai-Chia, Wong, Ying-Chieh, Hsieh, Chieh-Jui, Chen, Chiung-Tong, Kao, Tzu-Ting, Wu, Su-Ying, Yeh, Ching-Fang, Tseng, Chen-Tso, Chao, Yu-Sheng, Shia, Kak-Shan
Format: Article
Language:English
Subjects:
Animals
chemokines
CXCR4
Drug Evaluation, Preclinical
GPCRs
Hematopoietic Stem Cell Mobilization
Hematopoietic Stem Cells - cytology
Heterocyclic Compounds - chemistry
Heterocyclic Compounds - pharmacology
Injections, Subcutaneous
Male
Mice
Mice, Inbred C57BL
PBSC transplantation
Polyamines - chemistry
Pyrimidines - chemistry
Quinazolines - chemical synthesis
Quinazolines - chemistry
Quinazolines - pharmacology
Receptors, CXCR4 - antagonists & inhibitors
Receptors, CXCR4 - metabolism
Regenerative Medicine
SDF-1
structure-activity relationships
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Going mobile: Based on screening hit 1, a novel class of polyamine compounds, as represented by compound 8, were identified as potent and selective CXCR4 antagonists. CXCR4‐targeted molecules, as demonstrated by the marketed AMD3100 and 8, are able to mobilize stem cells from bone marrow effectively and are expected to have broad utility in cell therapy and regenerative medicine.
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.201100525