Solid phase microextraction, mass spectrometry and metabolomic approaches for detection of potential urinary cancer biomarkers—A powerful strategy for breast cancer diagnosis

► SPME useful to establishment of urinary volatile metabolomic pattern. ► Explore the VOMs as potential biomarkers in breast cancer diagnosis at early stage. ► Positive rates of 6 VOMs among the 79 detected were statistically different (p

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Bibliographic Details
Published in:Talanta (Oxford) 2012-01, Vol.89, p.360-368
Main Authors: Silva, Catarina L., Passos, Mário, Câmara, José S.
Format: Article
Language:English
Subjects:
Adsorption
Adult
Aged
Analytical chemistry
Biomarkers, Tumor - urine
Breast cancer
Breast Neoplasms - diagnosis
Breast Neoplasms - urine
Case-Control Studies
Chemistry
Chromatographic methods and physical methods associated with chromatography
Early Diagnosis
Exact sciences and technology
Female
Gas chromatographic methods
Gas Chromatography-Mass Spectrometry - methods
Humans
Male
Middle Aged
Multivariate Analysis
Principal Component Analysis
Solid Phase Microextraction - methods
Solid-phase microextraction
Spectrometric and optical methods
Urine samples
Volatile organic metabolites
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Description
Summary:► SPME useful to establishment of urinary volatile metabolomic pattern. ► Explore the VOMs as potential biomarkers in breast cancer diagnosis at early stage. ► Positive rates of 6 VOMs among the 79 detected were statistically different (p
ISSN:0039-9140
1873-3573
DOI:10.1016/j.talanta.2011.12.041