CD16+ natural killer cells play a limited role against primary dengue virus infection in tamarins

CD16 is a major molecule expressed on NK cells. To directly assess the role of natural killer (NK) cells in dengue virus (DENV) infection in vivo , CD16 antibody-treated tamarins were inoculated with a DENV-2 strain. This resulted in the transient depletion of CD16 + NK cells, whereas no significant...

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Bibliographic Details
Published in:Archives of virology 2012-02, Vol.157 (2), p.363-368
Main Authors: Yoshida, Tomoyuki, Omatsu, Tsutomu, Saito, Akatsuki, Katakai, Yuko, Iwasaki, Yuki, Iijima, Sayuki, Kurosawa, Terue, Hamano, Masataka, Nakamura, Shinichiro, Takasaki, Tomohiko, Yasutomi, Yasuhiro, Kurane, Ichiro, Akari, Hirofumi
Format: Article
Language:English
Subjects:
Animals
Antibodies, Viral - immunology
Arboviroses
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Brief Report
CD16 antigen
Dengue
Dengue - immunology
Dengue - virology
Dengue fever
Dengue fevers
Dengue Virus - immunology
Dengue Virus - physiology
Disease Models, Animal
Fundamental and applied biological sciences. Psychology
Human viral diseases
Humans
Infectious Diseases
Killer Cells, Natural - immunology
Leontopithecus
Medical Microbiology
Medical sciences
Microbiology
Miscellaneous
Natural killer cells
Receptors, IgG - immunology
Tropical viral diseases
Viral diseases
Virology
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Summary:CD16 is a major molecule expressed on NK cells. To directly assess the role of natural killer (NK) cells in dengue virus (DENV) infection in vivo , CD16 antibody-treated tamarins were inoculated with a DENV-2 strain. This resulted in the transient depletion of CD16 + NK cells, whereas no significant effects on the overall levels or kinetics of plasma viral loads and antiviral antibodies were observed in the treated monkeys when compared to control monkeys. It remains elusive whether the CD16 − NK subpopulation could play an important role in the control of primary DENV infection.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-011-1178-6