Arteriogenesis versus angiogenesis in peripheral artery disease

Summary Different forms of vessel growth in the adult organism contribute to the compensation for an occluded artery. We here summarize the major differences between arteriogenesis and angiogenesis and provide evidence in favour of a therapeutic stimulation of collateral growth. In addition, we outl...

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Bibliographic Details
Published in:Diabetes/metabolism research and reviews 2012-02, Vol.28 (S1), p.27-29
Main Authors: Troidl, Kerstin, Schaper, Wolfgang
Format: Article
Language:English
Subjects:
Adult
angiogenesis
arterial occlusion
Arterial Occlusive Diseases - physiopathology
Arterial Occlusive Diseases - therapy
arteriogenesis
Collateral Circulation
fluid shear stress
Humans
Neovascularization, Physiologic
nitric oxide
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Summary:Summary Different forms of vessel growth in the adult organism contribute to the compensation for an occluded artery. We here summarize the major differences between arteriogenesis and angiogenesis and provide evidence in favour of a therapeutic stimulation of collateral growth. In addition, we outline current knowledge about regulatory mechanisms transducing the initial physical stimulus into a cellular response. As an example, the role of nitric oxide during arteriogenesis is discussed, and finally, we propose a mechanism of how an efficient decision is made that makes the larger collaterals larger and the smaller ones smaller. Copyright © 2012 John Wiley & Sons, Ltd.
ISSN:1520-7552
1520-7560
DOI:10.1002/dmrr.2232