Obesity and breast cancer: A clinical biochemistry perspective

To evaluate the laboratory diagnosis aspects of obesity-related health problems with special reference to postmenopausal breast cancer. We conducted a systemic search of the literature primarily from the PubMed to obtain the relevant data. Obesity is associated with the dysregulations of a number of...

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Bibliographic Details
Published in:Clinical biochemistry 2012-02, Vol.45 (3), p.189-197
Main Authors: Ray, Amitabha, Cleary, Margot P.
Format: Article
Language:English
Subjects:
Adiposity
Biological and medical sciences
Biomedical Research
Breast Neoplasms - complications
Breast Neoplasms - metabolism
Female
Gynecology. Andrology. Obstetrics
Humans
Insulin Resistance
Intercellular Signaling Peptides and Proteins - metabolism
Investigative techniques, diagnostic techniques (general aspects)
Lab-diagnosis
Leptin
Leptin - metabolism
Lipids
Mammary gland diseases
Medical sciences
Metabolic diseases
Neoplasia
Obesity
Obesity - complications
Obesity - metabolism
Postmenopause
Tumors
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Summary:To evaluate the laboratory diagnosis aspects of obesity-related health problems with special reference to postmenopausal breast cancer. We conducted a systemic search of the literature primarily from the PubMed to obtain the relevant data. Obesity is associated with the dysregulations of a number of body components such as blood constituents, extracellular matrix, and hormones/growth factors axes, which could be utilized for early diagnosis. Obesity-related disorders including breast cancer have emerged as major health problems in almost all the nations. There is a need to elucidate different biochemical markers that are being used in the clinics or have the potential for such use. A precise understanding of the complex pathologies related with obesity is useful in prevention, early diagnosis and overall clinical management.
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2011.11.016