Diagnostic Value of Interferon- gamma Release Assays (QuantiFERON-TB Gold® In Tube) in Childhood Tuberculosis

Objective To evaluate the efficacy and diagnostic potential of interferon- gamma release assays QuantiFERON-TB Gold® In Tube (QFT-TB-IT) for the detection of gamma interferon against the antigen ESAT-6, CFP-10, TB 7.7(p4) of Mycobacterium tuberculosis and compare the reactivity with other methods (s...

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Bibliographic Details
Published in:Indian journal of pediatrics 2012-02, Vol.79 (2), p.183-187
Main Authors: Dayal, Rajeshwar, Verma, Vikas, Sharma, B., Kumar, G., Kumar, N., Gupta, R., Katoch, V. M., Joshi, Beenu, Chauhan, D. S.
Format: Article
Language:English
Subjects:
Bacterial diseases
Biological and medical sciences
Child
Female
General aspects
Gynecology
Human bacterial diseases
Humans
Infectious diseases
Interferon-gamma Release Tests
Male
Medical sciences
Medicine
Medicine & Public Health
Original Article
Pediatrics
Tuberculosis - diagnosis
Tuberculosis and atypical mycobacterial infections
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Summary:Objective To evaluate the efficacy and diagnostic potential of interferon- gamma release assays QuantiFERON-TB Gold® In Tube (QFT-TB-IT) for the detection of gamma interferon against the antigen ESAT-6, CFP-10, TB 7.7(p4) of Mycobacterium tuberculosis and compare the reactivity with other methods (smear, culture and IS6110 targeting PCR). Methods The study was carried out on children with pulmonary and extra pulmonary tuberculosis along with matching and PPD+ controls (82 cases, 48 matching controls and 20 PPD+ controls). Results QFT-TB-IT showed a significantly higher sensitivity (51.2%) as compared with LJ medium culture method (11.0%; p  
ISSN:0019-5456
0973-7693
DOI:10.1007/s12098-011-0469-y