Polymorphism in chemokine receptor genes and risk of acute myocardial infarction in North Indian population

Chemokines regulates the trafficking of leukocytes to the site of inflammation hence may be implicated in cardiac events. Currently no consistent effects have been revealed their role in acute myocardial infarction (MI). The aim of current study was to investigate the impact of human chemokine recep...

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Bibliographic Details
Published in:Molecular biology reports 2012-03, Vol.39 (3), p.2753-2759
Main Authors: Singh, Neha, Sinha, Nakul, Kumar, Sudeep, Pandey, Chandra M., Agrawal, Suraksha
Format: Article
Language:English
Subjects:
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
CCR5 protein
Chemokine receptors
Chemokines
CX3C Chemokine Receptor 1
CX3CR1 protein
DNA Mutational Analysis
DNA Primers - genetics
Gene Frequency
Gene polymorphism
Genes
Genetic Association Studies
Genetic diversity
Genetic Predisposition to Disease - genetics
Heart
Heart attacks
Histology
Humans
India - epidemiology
Inflammation
Insertion
Leukocyte migration
Leukocytes
Life Sciences
Morphology
Myocardial infarction
Myocardial Infarction - epidemiology
Myocardial Infarction - genetics
Neurons
Odds Ratio
Polymorphism
Polymorphism, Genetic - genetics
Receptors, CCR5 - genetics
Receptors, Chemokine - genetics
Risk Factors
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Summary:Chemokines regulates the trafficking of leukocytes to the site of inflammation hence may be implicated in cardiac events. Currently no consistent effects have been revealed their role in acute myocardial infarction (MI). The aim of current study was to investigate the impact of human chemokine receptor genetic variants, CCR5-Δ32 insertion/deletion, CCR5-59029-A/G, CX3CR1-V249I and CX3CR1-T280 M on acute MI. 230 acute MI and 300 controls were examined. Patients carrying CCR5-Δ32 genotype were at three times higher risk of developing MI odds ratio (OR, 3.24, CI 1.127–9.356, P  = 0.04). Significant association was found with risk of acute MI in recipients who possessed homozygous 59029-A allele (OR 1.47, CI 1.03–2.09, P  = 0.03). While CX3CR1-I249 and M280 were found to be protective in MI patients with OR 0.46, CI 0.32–0.66, P  
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-011-1031-8