Highly selective, naked-eye and fluorescent "off-on" probe for detection of histidine/histidine-rich proteins and its application in living cell imaging

A highly selective colorimetric and fluorescence enhanced probe S1 (M2@Cu) for histidine and histidine-rich proteins has been developed. In neutral aqueous ethanol solution, probe S1 can selectively detect histidine out of twenty DNA encoded amino acids by showing a color change from brownish red to...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2012-02, Vol.10 (8), p.1653-1658
Main Authors: Zhang, Shenyi, Yang, Chunmei, Zhu, Weiping, Zeng, Bubing, Yang, Youjun, Xu, Yufang, Qian, Xuhong
Format: Article
Language:English
Subjects:
Cell Survival
Fluorescent Dyes - analysis
Fluorescent Dyes - chemistry
HeLa Cells
Humans
Molecular Structure
Proteins - analysis
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Summary:A highly selective colorimetric and fluorescence enhanced probe S1 (M2@Cu) for histidine and histidine-rich proteins has been developed. In neutral aqueous ethanol solution, probe S1 can selectively detect histidine out of twenty DNA encoded amino acids by showing a color change from brownish red to light green, and with a fluorescence enhancement up to 99-fold at 537 nm, simultaneously.
ISSN:1477-0520
1477-0539
DOI:10.1039/c2ob06520g