A copper-based catalytic system for carboxylation of terminal alkynes: synthesis of alkyl 2-alkynoates

An efficient coupling of terminal alkynes and CO(2) in the presence of alkyl halides can be achieved under ambient conditions using a copper/phosphine catalyst system, providing facile access to a variety of functionalised alkyl 2-alkynoates.

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2012-02, Vol.10 (8), p.1514-1516
Main Authors: Inamoto, Kiyofumi, Asano, Narumi, Kobayashi, Koji, Yonemoto, Misato, Kondo, Yoshinori
Format: Article
Language:English
Subjects:
Alkynes - chemistry
Carbon Dioxide - chemistry
Catalysis
Copper - chemistry
Molecular Structure
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Description
Summary:An efficient coupling of terminal alkynes and CO(2) in the presence of alkyl halides can be achieved under ambient conditions using a copper/phosphine catalyst system, providing facile access to a variety of functionalised alkyl 2-alkynoates.
ISSN:1477-0520
1477-0539
DOI:10.1039/c2ob06884b