Effects of ritanserin and 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) in the murine elevated plus-maze test of anxiety: an ethopharmacological study

The 5-HT2A/2c receptor antagonist, ritanserin, has produced highly variable results in animal models of anxiety. The present study addressed the effects of this compound (0.5-5.0 mg/kg) and those of the 5-HT2A/2C receptor agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (0.25-1.0 mg/kg), in an...

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Bibliographic Details
Published in:Journal of psychopharmacology (Oxford) 1995-01, Vol.9 (1), p.38-42
Main Authors: Rodgers, R.J., Johnson, N.J.T., Norton, S.J., Cole, J.C.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
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Summary:The 5-HT2A/2c receptor antagonist, ritanserin, has produced highly variable results in animal models of anxiety. The present study addressed the effects of this compound (0.5-5.0 mg/kg) and those of the 5-HT2A/2C receptor agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (0.25-1.0 mg/kg), in an ethological version of the murine elevated plus-maze paradigm. In marked contrast to the potent effects produced by other compounds (anxiolytic and anxiogenic) under identical test conditions, results show that, over the dose ranges tested, neither compound significantly altered behavioural profiles. Findings are discussed in relation to the question of receptor affinities and the need for studies on compounds with more selective profiles of action.
ISSN:0269-8811
1461-7285
DOI:10.1177/026988119500900107