Efficacy of QCDCR formulated CpG ODN 2007 in Nile tilapia against Streptococcus iniae and identification of upregulated genes

The potential of using a QCDCR (quilA:cholesterol:dimethyl dioctadecyl ammonium bromide:carbopol:R1005 glycolipid) formulated CpG oligodeoxynucleotide (ODN), ODN 2007, to confer protection in Nile tilapia against Streptococcus iniae infection was evaluated in this study. At two days post treatment,...

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Bibliographic Details
Published in:Veterinary immunology and immunopathology 2012-01, Vol.145 (1-2), p.179-190
Main Authors: Pridgeon, Julia W., Klesius, Phillip H., Mu, Xingjiang, Yancey, Robert J., Kievit, Michele S., Dominowski, Paul J.
Format: Article
Language:English
Subjects:
Animals
bacterial infections
cDNA libraries
Cichlids - genetics
Cichlids - immunology
Cichlids - microbiology
complementary DNA
CpG Islands
CpG oligodeoxynucleotide
DNA, Complementary - genetics
Expressed Sequence Tags
Fish Diseases - immunology
Fish Diseases - microbiology
Fish Diseases - prevention & control
gene expression regulation
immunity
Immunity - drug effects
Immunity - genetics
Molecular Sequence Data
Oligodeoxyribonucleotides - therapeutic use
oligonucleotides
Oreochromis niloticus
polymerase chain reaction
Polymerase Chain Reaction - veterinary
Sarcosine Oxidase - genetics
Sarcosine Oxidase - metabolism
Streptococcal Infections - immunology
Streptococcal Infections - veterinary
Streptococcus - immunology
Streptococcus iniae
Subtractive hybridization
Up-Regulation - drug effects
Upregulation
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Summary:The potential of using a QCDCR (quilA:cholesterol:dimethyl dioctadecyl ammonium bromide:carbopol:R1005 glycolipid) formulated CpG oligodeoxynucleotide (ODN), ODN 2007, to confer protection in Nile tilapia against Streptococcus iniae infection was evaluated in this study. At two days post treatment, QCDCR formulated ODN 2007 elicited significant (P
ISSN:0165-2427
1873-2534
DOI:10.1016/j.vetimm.2011.11.001