Chronic bilateral subthalamic stimulation after anterior callosotomy in drug-resistant epilepsy: Long-term clinical and functional outcome of two cases

Summary We explored the efficacy and safety of bilateral SubThalamic Nucleus (STN) stimulation in two subjects suffering from drug-resistant epilepsy even after anterior callosotomy. Case 1 had about 65% decrease of partial motor seizures and the complete disappearance of tonic–clonic generalized at...

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Bibliographic Details
Published in:Epilepsy research 2012-02, Vol.98 (2), p.135-139
Main Authors: Capecci, Marianna, Ricciuti, Riccardo A, Ortenzi, Andrea, Paggi, Aldo, Durazzi, Vasco, Rychlicki, Franco, Provinciali, Leandro, Scerrati, Massimo, Ceravolo, Maria Gabriella
Format: Article
Language:English
Subjects:
Adult
Anticonvulsants. Antiepileptics. Antiparkinson agents
Biological and medical sciences
Callosotomy
Corpus Callosum - surgery
DBS
Deep Brain Stimulation - methods
Epilepsy
Epilepsy - therapy
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Longitudinal Studies
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Neuropharmacology
Outcome
Pharmacology. Drug treatments
Psychosurgery - methods
STN
Subthalamic Nucleus - physiology
Treatment Outcome
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Summary:Summary We explored the efficacy and safety of bilateral SubThalamic Nucleus (STN) stimulation in two subjects suffering from drug-resistant epilepsy even after anterior callosotomy. Case 1 had about 65% decrease of partial motor seizures and the complete disappearance of tonic–clonic generalized attacks. Case 2, with sudden drop (atonic) attacks, partial complex seizures, atypical absences and rare tonic–clonic seizures, showed no meaningful reduction of fits and a stimulation associated atypical absence rate increase.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2011.08.017