Pulmonary aspergillosis and HIV infection: about two cases

The occurrence of invasive pulmonary aspergillosis is unusual during the course of AIDS. Patients at risk have a CD4 T-lymphocyte count under 50 cells/mm(3) combined with other risk factors in 50% of the cases. Positive diagnosis is based on chest CT scan imaging and isolation of Aspergillus in bron...

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Bibliographic Details
Published in:Revue de pneumologie clinique 2012-02, Vol.68 (1), p.36-39
Main Authors: El Fane, M, Ouladlahsen, A, Bakhatar, A, Sodqi, M, El Filali, K Marhoum, Bahlaoui, A, Chakib, A
Format: Article
Language:fre
Subjects:
Adult
Antifungal Agents - therapeutic use
Aspergillosis - diagnosis
Aspergillosis - diagnostic imaging
Bronchoalveolar Lavage
HIV Infections - complications
HIV Infections - diagnosis
Humans
Lung Diseases, Fungal - diagnosis
Lung Diseases, Fungal - diagnostic imaging
Lung Diseases, Fungal - drug therapy
Male
Middle Aged
Prognosis
Pulmonary Aspergillosis - complications
Pulmonary Aspergillosis - diagnosis
Pyrimidines - therapeutic use
Radiography
Risk Factors
Triazoles - therapeutic use
Voriconazole
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Summary:The occurrence of invasive pulmonary aspergillosis is unusual during the course of AIDS. Patients at risk have a CD4 T-lymphocyte count under 50 cells/mm(3) combined with other risk factors in 50% of the cases. Positive diagnosis is based on chest CT scan imaging and isolation of Aspergillus in broncho-alveolar fluid. Detection of galactomannan antigen in serum and broncho-alveolar lavage fluid (BALF) is a reliable complementary tool in assessing the diagnosis. The first line therapy is Voriconazole. The prognosis, often severe, depends on prompt initiation of the appropriate antifungal treatment. We report two cases of invasive pulmonary aspergillosis in AIDS patients.
ISSN:0761-8417
DOI:10.1016/j.pneumo.2011.05.005