Geographic structuring of global EIAV isolates: A single origin for New World strains?

Equine infectious anaemia virus (EIAV) is classified within the Retroviridae and, like other lentivirus, has the propensity for considerable antigenic variation. An extensive phylogenetic analysis in Bayesian fashion, with significant amounts of new EIAV gag sequence information, revealed a strong g...

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Bibliographic Details
Published in:Virus research 2012-02, Vol.163 (2), p.656-659
Main Authors: Capomaccio, Stefano, Cappelli, Katia, Cook, R. Frank, Nardi, Francesco, Gifford, Robert, Marenzoni, Maria Luisa, Passamonti, Fabrizio
Format: Article
Language:English
Subjects:
Animals
Cluster Analysis
Eiav
Equine Infectious Anemia - epidemiology
Equine Infectious Anemia - virology
Gene Products, gag - genetics
Global Health
Horse
Horses
Infectious Anemia Virus, Equine - classification
Infectious Anemia Virus, Equine - genetics
Infectious Anemia Virus, Equine - isolation & purification
Molecular Epidemiology
Phylogenetic analysis
Phylogeography
Sequence Analysis, DNA
Sequence Homology
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Summary:Equine infectious anaemia virus (EIAV) is classified within the Retroviridae and, like other lentivirus, has the propensity for considerable antigenic variation. An extensive phylogenetic analysis in Bayesian fashion, with significant amounts of new EIAV gag sequence information, revealed a strong geographic compartmentalization clearly related to the phylogeographic history of modern horses, pointing out that New World EIAV strains form a distinct group with a potentially common origin. This evidence suggests that a single founder event may have occurred during the reintroduction of horses to the Americas by European colonists in the 15th century, a possibility that raises many interesting scenarios with implications for all evolutionary and ecological studies.
ISSN:0168-1702
1872-7492
DOI:10.1016/j.virusres.2011.11.011