The formulation of polyhedral boranes for the boron neutron capture therapy of cancer

The early promise of boron neutron capture therapy as a method for the treatment of cancer has been inhibited by the inherent toxicity associated with therapeutically useful doses of 10B-containing pharmacophores, the need for target-tissue specificity and the challenges imposed by biological barrie...

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Bibliographic Details
Published in:Drug discovery today 2012-02, Vol.17 (3-4), p.153-159
Main Authors: Calabrese, Gianpiero, Nesnas, John J., Barbu, Eugen, Fatouros, Dimitris, Tsibouklis, John
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biological Transport
Boranes - chemistry
Boranes - pharmacokinetics
Boron Compounds - adverse effects
Boron Compounds - chemistry
Boron Compounds - pharmacokinetics
Boron Neutron Capture Therapy - adverse effects
Boron Neutron Capture Therapy - methods
General pharmacology
Humans
Medical sciences
Neoplasms - radiotherapy
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
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Summary:The early promise of boron neutron capture therapy as a method for the treatment of cancer has been inhibited by the inherent toxicity associated with therapeutically useful doses of 10B-containing pharmacophores, the need for target-tissue specificity and the challenges imposed by biological barriers. Although developments in the synthetic chemistry of polyhedral boranes have addressed issues of toxicity to a considerable extent, the optimisation of the transport and the delivery of boronated agents to the site of action – the subject of this review – is a challenge that is addressed by the development of innovative formulation strategies.
ISSN:1359-6446
1878-5832
DOI:10.1016/j.drudis.2011.09.014