Application of the Refined Integral Method in the mathematical modeling of drug delivery from one-layer torus-shaped devices

The Refined Integral Method has been successfully applied to moving boundary problems encountered in the diffusional release of solutes from torus-shaped single-layer devices. A mathematical modeling of controlled release of drug from one-layer torus-shaped devices is presented. Analytical solutions...

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Bibliographic Details
Published in:International journal of pharmaceutics 2012-02, Vol.423 (2), p.240-246
Main Authors: Helbling, Ignacio M., Ibarra, Juan C.D., Luna, Julio A.
Format: Article
Language:English
Subjects:
Administration, Intravaginal
Animals
Chemistry, Pharmaceutical
Computer Simulation
Contraceptive Devices, Female
Controlled release
Data processing
Delayed-Action Preparations
Diffusion
Dispersed drug
Drug Carriers
Drug Compounding
Drug delivery
Female
Humans
Intravaginal ring
Kinetics
Mathematical modeling
Mathematical models
Models, Chemical
Models, Statistical
Moving front
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Preparations - chemistry
Polymers - chemistry
Refined Integral Method
Reproducibility of Results
Solubility
Technology, Pharmaceutical - methods
Vagina
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Summary:The Refined Integral Method has been successfully applied to moving boundary problems encountered in the diffusional release of solutes from torus-shaped single-layer devices. A mathematical modeling of controlled release of drug from one-layer torus-shaped devices is presented. Analytical solutions based on Refined Integral Method (RIM) are derived. The validity and utility of the model are ascertained by comparison of the simulation results with matrix-type vaginal rings experimental release data reported in the literature. For the comparisons, the pair-wise procedure is used to measure quantitatively the fit of the theoretical predictions to the experimental data. A good agreement between the model prediction and the experimental data is observed. A comparison with a previously reported model is also presented. More accurate results are achieved for small A/Cs ratios.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2011.12.005