The clinicopathological features of intraductal papillary neoplasms of the bile duct in a Chinese population

• Published in: Digestive and liver disease 2012-03, Vol.44 (3), p.251-256
• Main Authors: Yang, Jian, Wang, Wentao, Yan, Lunan
• Format: Article
• Language: English
• Subjects: Adenoma - pathology; Adenoma - surgery; Aged; Analysis of Variance; Asian Continental Ancestry Group; Bile Duct Neoplasms - diagnostic imaging; Bile Duct Neoplasms - pathology; Bile Duct Neoplasms - surgery; Biliary neoplasms; Carcinoma, Papillary - diagnostic imaging; Carcinoma, Papillary - pathology; Carcinoma, Papillary - surgery; China; Clinicopathologic characteristics; Female; Gastroenterology and Hepatology; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Retrospective Studies; Surgery; Survivors; Tomography, X-Ray Computed; Ultrasonography
• ISSN: 1590-8658; 1878-3562
• DOI: 10.1016/j.dld.2011.08.014

Abstract Background Intraductal papillary neoplasms of the bile duct have been applied to certain types of papillary tumours occurring in the biliary tract. Although many cases have been sporadically reported, there remain controversies. Aims To analyze the clinicopathologic characteristics and long-term survival of intraductal papillary neoplasms of the bile duct. Methods The clinicopathologic data of 52 patients who underwent surgery for intraductal papillary neoplasms of the bile duct were retrospectively evaluated. Results In our series, tumours located in intrahepatic and hilar bile duct, rather than in extrahepatic bile duct, were more commonly diagnosed as adenomas or borderline tumours (12/19 and 7/13 vs 6/20; P = 0.046). And the gastric type was more commonly associated with adenomas or borderline tumour (85.7%), whilst the pancreaticobiliary type mainly comprised of noninvasive carcinoma or invasive carcinoma (93.8%). However, only the types of treatment (median survival: curative resection: 72 months and palliative groups: 12 months; P < 0.001) and histologic grades (adenoma or borderline malignancy vs noninvasive carcinoma: P = 0.018) were significantly associated with survival. Conclusion Intraductal papillary neoplasms of the bile duct are rare type of biliary neoplasms, long-term survival may be achieved with complete resection. However, further studies are needed to clarify the relationship between these variables like location, cellular types and histologic grades.