The central versus peripheral antinociceptive effects of μ-opioid receptor agonists in the new model of rat visceral pain

Highlights ► DAMGO and morphine were analgesics in the rat model of late permanent visceral pain. ► DAMGO was equipotent with morphine by i.p. and more potent by i.c.v. administration. ► To demonstrate the site of action of drugs, a quaternary opioid antagonist was used. ► The effect of i.p. DAMGO i...

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Bibliographic Details
Published in:Brain research bulletin 2012-02, Vol.87 (2), p.238-243
Main Authors: Al-Khrasani, Mahmoud, Lackó, Erzsébet, Riba, Pál, Király, Kornél, Sobor, Melinda, Timár, Júlia, Mousa, Shaaban, Schäfer, Michael, Fürst, Susanna
Format: Article
Language:English
Subjects:
Acetic Acid - toxicity
Analgesics, Opioid - therapeutic use
Analysis of Variance
Animals
Antinociception
DAMGO
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Administration Routes
Drug Interactions
Enkephalin, Ala-MePhe-Gly- - therapeutic use
Morphine
Morphine - therapeutic use
Naloxone - administration & dosage
Naloxone - analogs & derivatives
Narcotic Antagonists - administration & dosage
Neurology
Peripheral MOR
Quaternary Ammonium Compounds - administration & dosage
Rat acetic acid induced late permanent visceral pain
Rats
Visceral Pain - chemically induced
Visceral Pain - drug therapy
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Summary:Highlights ► DAMGO and morphine were analgesics in the rat model of late permanent visceral pain. ► DAMGO was equipotent with morphine by i.p. and more potent by i.c.v. administration. ► To demonstrate the site of action of drugs, a quaternary opioid antagonist was used. ► The effect of i.p. DAMGO is predominantly mediated by peripheral opioid receptors. ► The effect of i.p. morphine is mediated by central and peripheral opioid receptors.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2011.10.018