Everolimus with Reduced-dose Cyclosporine Versus Full-dose Cyclosporine and Mycophenolate in De Novo Renal Transplant Patients: A 2-Year Single-Center Experience

Abstract Background Although calcineurin inhibitors (CNIs) has improved short-term graft survival, long-term function remains a challenge. CNIs have been implicated in the development of chronic allograft failure. Low-dose cyclosporine with everolimus may mitigate CNI nephrotoxicity and prolong graf...

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Bibliographic Details
Published in:Transplantation proceedings 2012, Vol.44 (1), p.154-160
Main Authors: Santos, S.M, Carlos, C.M, Cabanayan-Casasola, C.B, Danguilan, R.A
Format: Article
Language:English
Subjects:
Adult
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
Cyclosporine - administration & dosage
Cyclosporine - adverse effects
Cyclosporine - blood
Cyclosporine - pharmacokinetics
Drug Monitoring
Drug Therapy, Combination
Everolimus
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Graft Rejection - immunology
Graft Rejection - prevention & control
Graft Survival - drug effects
Humans
Immunosuppressive Agents - administration & dosage
Immunosuppressive Agents - adverse effects
Immunosuppressive Agents - blood
Immunosuppressive Agents - pharmacokinetics
Kidney Transplantation - immunology
Linear Models
Living Donors
Logistic Models
Male
Medical sciences
Middle Aged
Mycophenolic Acid - administration & dosage
Mycophenolic Acid - adverse effects
Mycophenolic Acid - blood
Mycophenolic Acid - pharmacokinetics
Pharmacology. Drug treatments
Philippines
Retrospective Studies
Sirolimus - administration & dosage
Sirolimus - adverse effects
Sirolimus - analogs & derivatives
Sirolimus - blood
Sirolimus - pharmacokinetics
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tissue, organ and graft immunology
Treatment Outcome
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Summary:Abstract Background Although calcineurin inhibitors (CNIs) has improved short-term graft survival, long-term function remains a challenge. CNIs have been implicated in the development of chronic allograft failure. Low-dose cyclosporine with everolimus may mitigate CNI nephrotoxicity and prolong graft survival. We compared the efficacy and safety of de novo everolimus with low-dose cyclosporine and prednisone versus cyclosporine, mycophenolate, and prednisone among kidney transplant patients up to 24 months after transplantation. Methods Kidney transplant patients given low-dose cyclosporine, everolimus, and prednisone were compared with patients given cyclosporine, mycophenolate, and prednisone from December 2006 to December 2008. All had living donors, panel reactive antibody
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2011.11.055