Chronic brain hypoperfusion causes early glial activation and neuronal death, and subsequent long-term memory impairment

Highlights ► Carotids were occluded with 1 week interval in the modified two-vessel occlusion. ► Modified 2VO causes long-term memory impairment. ► Neuronal damage and reactive astrogliosis happens in the acute phase. ► Cognitive behavior installed in stages more chronic of the model.

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Bibliographic Details
Published in:Brain research bulletin 2012-01, Vol.87 (1), p.109-116
Main Authors: Cechetti, Fernanda, Pagnussat, Aline S, Worm, Paulo V, Elsner, Viviane Rostirolla, Ben, Juliana, da Costa, Marcelo Siveira, Mestriner, Régis, Weis, Simone Nardin, Netto, Carlos Alexandre
Format: Article
Language:English
Subjects:
2VO-ischemia memory impairment
Animals
Behavior, Animal - physiology
Brain - anatomy & histology
Brain - blood supply
Brain - pathology
Brain - physiopathology
Cell Death - physiology
chronic cerebral hypoperfusion
Glia
Hippocampus
Male
Maze Learning - physiology
Memory Disorders - pathology
Memory Disorders - physiopathology
Memory impairment
Memory, Long-Term - physiology
Neuroglia - pathology
Neuroglia - physiology
Neurology
Neuron
Neurons - cytology
Neurons - pathology
Rats
Rats, Wistar
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Description
Summary:Highlights ► Carotids were occluded with 1 week interval in the modified two-vessel occlusion. ► Modified 2VO causes long-term memory impairment. ► Neuronal damage and reactive astrogliosis happens in the acute phase. ► Cognitive behavior installed in stages more chronic of the model.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2011.10.006