HORMONES AS A RISK FACTOR OF TUMOR OCCURENCE AND ITS PROGRESSION

Aim: To assess the frequency of abnormal levels of selected hormones in patients with malignant diseases in comparison with occurrence of hormone abnormalities in the population and their relationship to the biological activity of the tumour. Methods: Serum levels of insulin like growth factor 1 (IG...

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Bibliographic Details
Published in:Anticancer research 2011-05, Vol.31 (5), p.2005-2006
Main Authors: Topolcan, O, Fuchsova, R, Svobodova, S, Vrzalova, J, Kucera, R, Treska, V
Format: Article
Language:English
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Summary:Aim: To assess the frequency of abnormal levels of selected hormones in patients with malignant diseases in comparison with occurrence of hormone abnormalities in the population and their relationship to the biological activity of the tumour. Methods: Serum levels of insulin like growth factor 1 (IGF-I), insulin, prolactin, thyroid stimulating hormone (TSH), autoantibodies against thyroid peroxidase (aTPO)and 25OH-vitamin D using routine immunoassays were measured in 850 patients with carcinoma of breast, lung, prostate or colorectum. Results: Significantly higher frequencies of hypothyreosis were observed in patients with carcinoma of breast or colorectum, and a significantly higher rate of insulinoresistance and hyperprolactinemie in colorectal cancer. Differences in insulin levels and aTPO positivity were correlated to the stage of disease. In all carcinomas, a decreased level of 25-OH vitamin D was observed. In carcinoma patients, IGF-1 was by 40-70% (according to type of tumour) out of the reference ranges. Conclusion: The hormonal situation in cases of malignant tumours may provide information on the ethiopathogenesis of the malignant process and its prevention.
ISSN:0250-7005