The beneficial effects of deferred delivery on the efficiency of hydrogel therapy post myocardial infarction

Abstract Biomaterials are increasingly being investigated as a means of reducing stress within the ventricular wall of infarcted hearts and thus attenuating pathological remodelling and loss of function. In this context, we have examined the influence of timing of delivery on the efficacy of a polye...

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Bibliographic Details
Published in:Biomaterials 2012-03, Vol.33 (7), p.2060-2066
Main Authors: Kadner, Karen, Dobner, Stephan, Franz, Thomas, Bezuidenhout, Deon, Sirry, Mazin S, Zilla, Peter, Davies, Neil H
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Biocompatible Materials - therapeutic use
Dentistry
Drug Delivery Systems
Heart
Heart - drug effects
Humans
Hydrogel
Hydrogels - chemistry
Hydrogels - pharmacology
Hydrogels - therapeutic use
Infarction
Male
Myocardial Infarction - drug therapy
Myocardial Infarction - pathology
Polyethylene Glycols - chemistry
Polyethylene Glycols - pharmacology
Polyethylene Glycols - therapeutic use
Rats
Rats, Wistar
Remodelling
Ventricular Remodeling - drug effects
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Summary:Abstract Biomaterials are increasingly being investigated as a means of reducing stress within the ventricular wall of infarcted hearts and thus attenuating pathological remodelling and loss of function. In this context, we have examined the influence of timing of delivery on the efficacy of a polyethylene glycol hydrogel polymerised with an enzymatically degradable peptide sequence. Delivery of the hydrogel immediately after infarct induction resulted in no observable improvements, but a delay of one week in delivery resulted in significant increases in scar thickness and fractional shortening, as well as reduction in end-systolic diameter against saline controls and immediately injected hydrogel at both 2 and 4 weeks post-infarction ( p  
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2011.11.031