Three novel alleles at the HLA-DRB1 locus identified by sequence-based typing

Abstract We describe here the sequences of 3 new HLA-DRB1 variants officially named DRB1*03:05:03, DRB1*11:10:02, and DRB1*14:86. These novel alleles have been detected in 3 Caucasoid individuals by sequence-based typing. The first and second alleles are the result of a silent mutation, which does n...

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Bibliographic Details
Published in:Human immunology 2012, Vol.73 (1), p.67-69
Main Authors: Frison, Sara, Longhi, Elena, Mantovani, Martina, Mantia, Monica, Tagliaferri, Cinzia, Di Giorgio, Daniela, Scalamogna, Mario, Poli, Francesca
Format: Article
Language:English
Subjects:
Alleles
Allergy and Immunology
Base Sequence
European Continental Ancestry Group - genetics
Genotyping Techniques - methods
HLA-DRB1 Chains - genetics
HLA-DRB103:05:03
HLA-DRB111:10:02
HLA-DRB114:86
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Polymorphism, Genetic
SBT
Sequence Analysis, DNA - methods
Sequence Homology, Nucleic Acid
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Summary:Abstract We describe here the sequences of 3 new HLA-DRB1 variants officially named DRB1*03:05:03, DRB1*11:10:02, and DRB1*14:86. These novel alleles have been detected in 3 Caucasoid individuals by sequence-based typing. The first and second alleles are the result of a silent mutation, which does not imply any amino acid change. The sequence of DRB1*14:86 exhibits a single nucleotide difference with the allele DRB1*14:01:01 at position 239.
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2011.11.004