The effects of polymeric nanostructure shape on drug delivery

Amphiphilic polymeric nanostructures have long been well-recognized as an excellent candidate for drug delivery applications. With the recent advances in the “top-down” and “bottom-up” approaches, development of well-defined polymeric nanostructures of different shapes has been possible. Such a poss...

Full description

Saved in:
Bibliographic Details
Published in:Advanced drug delivery reviews 2011-11, Vol.63 (14), p.1228-1246
Main Authors: Venkataraman, Shrinivas, Hedrick, James L., Ong, Zhan Yuin, Yang, Chuan, Ee, Pui Lai Rachel, Hammond, Paula T., Yang, Yi Yan
Format: Article
Language:English
Subjects:
Biodistribution
Cell Line
Cell Survival - drug effects
Cellular uptake
Cytotoxicity
Dendrimers
Drug Carriers - chemistry
Drug Carriers - pharmacokinetics
Drug Carriers - toxicity
Drug delivery
Elongated micelles
Endocytosis - drug effects
Humans
Micelles
Microfabrication
Nanostructures - chemistry
Particle Size
Phagocytosis - drug effects
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Vehicles - chemistry
Polymeric nanostructure
Polymers - chemistry
Polymers - pharmacokinetics
Polymers - toxicity
Self-assembly
Shape control
Shape effect
Solubility
Surface Properties
Technology, Pharmaceutical - instrumentation
Technology, Pharmaceutical - methods
Vesicles
Worm-like micelles
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Amphiphilic polymeric nanostructures have long been well-recognized as an excellent candidate for drug delivery applications. With the recent advances in the “top-down” and “bottom-up” approaches, development of well-defined polymeric nanostructures of different shapes has been possible. Such a possibility of tailoring the shape of the nanostructures has allowed for the fabrication of model systems with chemically equivalent but topologically different carriers. With these model nanostructures, evaluation of the importance of particle shape in the context of biodistribution, cellular uptake and toxicity has become a major thrust area. Since most of the current polymeric delivery systems are based upon spherical nanostructures, understanding the implications of other shapes will allow for the development of next generation drug delivery vehicles. Herein we will review different approaches to fabricate polymeric nanostructures of various shapes, provide a comprehensive summary on the current understandings of the influence of nanostructures with different shapes on important biological processes in drug delivery, and discuss future perspectives for the development of nanostructures with well-defined shapes for drug delivery. [Display omitted]
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2011.06.016