Serum microRNA-122 levels in different groups of patients with chronic hepatitis B virus infection

miR‐122 is a liver‐specific microRNA, which also circulates in the blood. The levels of miR‐122 in serum and plasma correlate with hepatic necroinflammation in patients with hepatitis B virus (HBV) infection. Here, we investigated whether miR‐122 levels correlate with surrogate markers for viral rep...

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Published in:Journal of viral hepatitis 2012-02, Vol.19 (2), p.e58-e65
Main Authors: Waidmann, O., Bihrer, V., Pleli, T., Farnik, H., Berger, A., Zeuzem, S., Kronenberger, B., Piiper, A.
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Biopsy
DNA, Viral - blood
Female
HBs antigen
HBV carrier
HBV DNA
hepatitis B
Hepatitis B Surface Antigens - blood
Hepatitis B virus
Hepatitis B virus - isolation & purification
Hepatitis B, Chronic - diagnosis
Hepatitis B, Chronic - pathology
Hepatitis B, Chronic - physiopathology
Histocytochemistry
Humans
Liver - pathology
Male
microRNA-122
MicroRNAs - blood
Middle Aged
Prognosis
Real-Time Polymerase Chain Reaction
Retrospective Studies
Serum - chemistry
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Summary:miR‐122 is a liver‐specific microRNA, which also circulates in the blood. The levels of miR‐122 in serum and plasma correlate with hepatic necroinflammation in patients with hepatitis B virus (HBV) infection. Here, we investigated whether miR‐122 levels correlate with surrogate markers for viral replication and translation. Furthermore, we examined whether miR‐122 levels differ in the different groups of HBV‐infected patients and whether miR‐122 levels may be useful to identify patients with higher or lower risk for liver disease progression. Therefore, RNA was extracted from sera of therapy‐naïve patients with HBV infection (n = 89) and from healthy volunteers (n = 19). The concentration of miR‐122 was assessed by quantitative real‐time reverse‐transcription PCR. HBs antigen and HBV DNA levels were quantified as surrogate parameters for HBV replication and translation. Liver biopsies were examined according to the histological activity index and the degree of fibrosis was assessed. We found that the miR‐122 serum concentration correlated with the level of ALT, HBV DNA and HBs antigen (r = 0.259, P 
ISSN:1352-0504
1365-2893
DOI:10.1111/j.1365-2893.2011.01536.x