Etiological analysis of presumed perinatal stroke

Abstract This study aimed to investigate the maternal, pre- and perinatal, and prothrombotic factors with congenital hemiparesis due to presumed perinatal stroke (PPS). Prothrombotic risk factors including protein C and S, antithrombin III, lipoprotein (a), homocystein, factor VIII levels; anticardi...

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Bibliographic Details
Published in:Brain & development (Tokyo. 1979) 2012-02, Vol.34 (2), p.133-139
Main Authors: Kocaman, Canan, Yilmaz, Yuksel
Format: Article
Language:English
Subjects:
Brain Infarction - diagnosis
Brain Infarction - etiology
Child, Preschool
Cross-Sectional Studies
Female
Humans
Infant
Magnetic Resonance Imaging
Male
Mother-Child Relations
Neurology
Prothrombin
Risk Factors
Stroke - complications
Stroke - diagnosis
Stroke - etiology
Stroke - genetics
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Summary:Abstract This study aimed to investigate the maternal, pre- and perinatal, and prothrombotic factors with congenital hemiparesis due to presumed perinatal stroke (PPS). Prothrombotic risk factors including protein C and S, antithrombin III, lipoprotein (a), homocystein, factor VIII levels; anticardiolipin antibodies and lupus anticoagulant; methylenetetrahydrofolate reductase mutations, factor V Leiden, prothrombin G20210A mutations were investigated. Arterial ischemic stroke was detected in 60% and periventricular venous infarction in 40%. At least one prothrombotic risk factor was present in 69%, two in 17%, and three or more in 8.5% of cases. The most common combination was methylenetetrahydrofolate reductase C677T and factor V Leiden heterozygosity. The etiology and pathogenesis of PPS is still unclear. According to this study, most of the patients with PPS might have one or more prothrombotic risk factors and certain prenatal risk factors including intrauterine growth retardation, twin gestation and preeclampsia might be related to PPS.
ISSN:0387-7604
1872-7131
DOI:10.1016/j.braindev.2011.04.003