Intrinsic magnetism and hyperthermia in bioactive Fe-doped hydroxyapatite

The use of magnetic activation has been proposed to answer the growing need for assisted bone and vascular remodeling during template/scaffold regeneration. With this in mind, a synthesis procedure was developed to prepare bioactive (Fe 2+/Fe 3+)-doped hydroxyapatite (Fe-HA), endowed with superparam...

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Bibliographic Details
Published in:Acta biomaterialia 2012-02, Vol.8 (2), p.843-851
Main Authors: Tampieri, Anna, D’Alessandro, Teresa, Sandri, Monica, Sprio, Simone, Landi, Elena, Bertinetti, Luca, Panseri, Silvia, Pepponi, Giancarlo, Goettlicher, Joerg, Bañobre-López, Manuel, Rivas, Jose
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Bone regeneration
Cell Adhesion - drug effects
ceramics
cytotoxicity
Durapatite - chemistry
Durapatite - pharmacology
fever
Hot Temperature
Hydroxyapatite
Hyperthermia
ions
iron
Iron - chemistry
Iron - pharmacology
iron oxides
Magnetic Fields
Magnetic properties
Magnetics
magnetism
magnetite
Microscopy, Electron, Transmission
Microscopy, Fluorescence
nanoparticles
Osteoblasts - cytology
Osteoblasts - drug effects
Oxidation-Reduction - drug effects
Powders
Rabbits
Superparamagnetism
surgery
X-Ray Absorption Spectroscopy
X-Ray Diffraction
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Summary:The use of magnetic activation has been proposed to answer the growing need for assisted bone and vascular remodeling during template/scaffold regeneration. With this in mind, a synthesis procedure was developed to prepare bioactive (Fe 2+/Fe 3+)-doped hydroxyapatite (Fe-HA), endowed with superparamagnetic-like properties. This new class of magnetic hydroxyapatites can be potentially employed to develop new magnetic ceramic scaffolds with enhanced regenerative properties for bone surgery; in addition, magnetic Fe-HA can find application in anticancer therapies, to replace the widely used magnetic iron oxide nanoparticles, whose long-term cytotoxicity was recently found to reach harmful levels. An extensive physicochemical, microstructural and magnetic characterization was performed on the obtained Fe-HA powders, and demonstrated that the simultaneous addition of Fe 2+ and Fe 3+ ions during apatite nucleation under controlled synthesis conditions induces intrinsic magnetization in the final product, minimizing the formation of magnetite as secondary phase. This result potentially opens new perspectives for biodevices aimed at bone regeneration and for anti-cancer therapies based on hyperthermia.
ISSN:1742-7061
1878-7568
DOI:10.1016/j.actbio.2011.09.032