Hemostatic Treatment Using Factor VIII Concentrates for Neutralizing High-Responding Inhibitors Prior to CVAD Insertion for Immune-Tolerance Induction Therapy

• Published in: Clinical and applied thrombosis/hemostasis 2012-01, Vol.18 (1), p.66-71
• Main Authors: Shibata, Masaru, Nakagawa, Takashi, Akioka, Shinji, Giddings, John C., Kanehiro, Hiromichi, Matsumoto, Tomoko, Ogiwara, Kenichi, Yada, Koji, Shima, Midori
• Format: Article
• Language: English
• Subjects: Blood Coagulation Factor Inhibitors - blood; Child; Child, Preschool; Factor VIII - administration & dosage; Factor VIII - economics; Hemophilia A - blood; Hemophilia A - drug therapy; Hemophilia A - economics; Hemostatics - administration & dosage; Hemostatics - economics; Humans; Infant; Male
• ISSN: 1076-0296; 1938-2723
• DOI: 10.1177/1076029611412364

We have utilized high-dose factor VIII (FVIII) concentrates in 4 hemophilia A patients with inhibitors prior to surgery for the insertion of a central venous access device. In total, 3 patients out of 4 had high responding inhibitors. Dosing algorithms for this type of therapy have not been previously validated and established. We devised an effective formula to calculate the initial dose required to neutralize the inhibitors, although some of the patients demonstrated a lower recovery of FVIII than expected. An anamnestic inhibitor response was evident in 3 cases, but overall our strategy provided a reliable hemostatic effect for at least 4 days after surgery. In addition, our protocol appeared to be more cost-effective than FVIII bypass therapy. The financial saving in 1 case for the initial 3 days was estimated to be approximately US$49 122. Our results demonstrated that high-dose FVIII therapy provided clinically effective and economically viable results even in high responders.