Metabolic and cardiovascular adjustments during psychological stress and carotid artery intima-media thickness in youth

• Published in: Physiology & behavior 2012-03, Vol.105 (5), p.1140-1147
• Main Authors: Lambiase, Maya J, Dorn, Joan, Roemmich, James N
• Format: Article
• Language: English
• Subjects: Adaptation, Physiological; Adolescent; adolescents; Age Factors; Behavioral psychophysiology; Biological and medical sciences; Blood Pressure - physiology; Cardiovascular Physiological Phenomena; Cardiovascular reactivity; carotid arteries; Carotid Arteries - anatomy & histology; childhood; Energy Metabolism - physiology; Exercise Test; Female; Fundamental and applied biological sciences. Psychology; Heart Rate; Humans; Intima-media thickness; Male; Metabolic demand; oxygen consumption; Psychiatry; psychological stress; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Reference Values; Sex Factors; sociodemographic characteristics; speech; Stress, Psychological - pathology; Stress, Psychological - physiopathology; systolic blood pressure; Tunica Intima - anatomy & histology; Tunica Media - anatomy & histology; ultrasonics; youth
• ISSN: 0031-9384; 1873-507X
• DOI: 10.1016/j.physbeh.2011.12.012

Abstract Objective Cardiovascular reactivity is associated with carotid artery intima-media thickness as early as childhood. Excess cardiovascular responses relative to the metabolic demand during psychological stress have been proposed as a mechanism for this association. However, it is not known whether excess cardiovascular responses in relation to the metabolic demand correlate with carotid artery intima-media thickness as strongly as traditionally measured cardiovascular reactivity. Methods Fifty-four adolescents, ages 13–16 years completed a graded exercise test in 1 day and measures of psychological stress reactivity (star tracing, speech) on another day. Heart rate, systolic blood pressure, and oxygen consumption were measured on both days. On a third visit adolescents completed an ultrasound scan to measure carotid artery intima-media thickness. Results Traditionally measured systolic blood pressure reactivity (β = 0.30, p = 0.02, R2 increase = 0.09) and excess systolic blood pressure (β = 0.30, p = 0.02, R2 increase = 0.08) while preparing a speech were associated with greater carotid artery intima-media thickness when controlling for demographic characteristics, fitness, and baseline systolic blood pressure. Conclusions This study adds to the growing body of literature showing a link between systolic blood pressure reactivity to acute psychological stress and carotid artery intima-media thickness in youth. This was the first study to demonstrate that systolic blood pressure in excess of the metabolic demand during psychological stress was also associated with carotid artery-intima media thickness.