The effects of haloperidol on cocaine-induced conditioned taste aversions

Abstract Although the mechanism underlying the rewarding effects of cocaine has been well characterized, little is known about the mechanism underlying its aversive effects. Several reports have indicated a possible role of dopamine (DA) in the aversive effects; however, several procedural issues li...

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Bibliographic Details
Published in:Physiology & behavior 2012-03, Vol.105 (5), p.1161-1167
Main Authors: Serafine, Katherine M, Briscione, Maria A, Riley, Anthony L
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Antagonism
Association Learning - drug effects
Avoidance Learning - drug effects
Behavioral psychophysiology
Biological and medical sciences
Cocaine
Cocaine - pharmacology
Conditioning, Classical - drug effects
CTA
Dopamine
Dopamine Agents - pharmacology
Dose-Response Relationship, Drug
Drug Interactions
Fundamental and applied biological sciences. Psychology
Haloperidol
Haloperidol - pharmacology
Male
Mechanism
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Psychiatry
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychopharmacology
Rats
Rats, Sprague-Dawley
Taste
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Summary:Abstract Although the mechanism underlying the rewarding effects of cocaine has been well characterized, little is known about the mechanism underlying its aversive effects. Several reports have indicated a possible role of dopamine (DA) in the aversive effects; however, several procedural issues limit any conclusions regarding its specific role. In order to investigate a possible dopaminergic role in cocaine-induced CTAs using procedures that circumvented these possible issues, the present series of investigations assessed the aversive effects of the DA antagonist haloperidol alone (Experiment 1) and in combination with cocaine (Experiment 2). Haloperidol, at doses that were determined to be non-aversive, yet behaviorally active in a locomotor assessment, attenuated cocaine-induced taste aversions, suggesting that cocaine's aversive effects are mediated in part by dopaminergic activity. These findings were discussed in consideration with other evidence implicating DA and other neurotransmitter systems in cocaine-induced CTAs.
ISSN:0031-9384
1873-507X
DOI:10.1016/j.physbeh.2011.12.014