25-hydroxyvitamin D, vitamin D receptor gene polymorphisms, and severity of Parkinson's disease

• Published in: Movement disorders 2012-02, Vol.27 (2), p.264-271
• Main Authors: Suzuki, Masahiko, Yoshioka, Masayuki, Hashimoto, Masaya, Murakami, Maiko, Kawasaki, Keiichi, Noya, Miki, Takahashi, Daisuke, Urashima, Mitsuyoshi
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Cohort Studies; Cross-Sectional Studies; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; Genetic Predisposition to Disease; Humans; Male; Medical sciences; Middle Aged; neurological disease; Neurology; Parkinson Disease - blood; Parkinson Disease - genetics; polymorphism; Polymorphism, Genetic; Receptors, Calcitriol - genetics; Severity of Illness Index; single nucleotide polymorphisms; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D - genetics; vitamin D binding protein; vitamin D receptor
• ISSN: 0885-3185; 1531-8257
• DOI: 10.1002/mds.24016

We aimed to examine associations among serum 25‐hydroxyvitamin D levels, 1,25‐dihyroxyvitamin D levels, vitamin D receptor polymorphisms, vitamin D binding protein gene polymorphisms, and the severity of Parkinson's disease. In 137 patients, the severity of Parkinson's disease was evaluated using Hoehn & Yahr stage and Unified Parkinson's Disease Rating Stage by neurologists and compared with 25‐hydroxyvitamin D, 1,25‐hydroxyvitamin D, vitamin D receptor polymorphisms, ie, FokI (rs10735810), BsmI (rs1544410), Cdx2 (rs11568820), ApaI (rs7976091), and TaqI (rs731236), and vitamin D binding protein gene polymorphisms GC1 (rs7041)/GC2 (rs4588) in a cross‐sectional study. Mean ± standard deviation levels of 25‐hydroxyvitamin D were 21.1 ± 9.0 ng/mL. Levels were deficient (