Comparison of efficacy of letrozole and clomiphene citrate in ovulation induction in Indian women with polycystic ovarian syndrome

Objectives The objective of this study was to compare the efficacy of letrozole versus clomiphene citrate as an ovulation induction drug in polycystic ovarian syndrome (PCOS) patients of Indian origin. Method One hundred and forty seven infertile PCOS patients were randomly given letrozole (2.5 mg)...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2012-03, Vol.285 (3), p.873-877
Main Authors: Banerjee Ray, Payal, Ray, Amitabh, Chakraborti, P. S.
Format: Article
Language:English
Subjects:
Adult
Chorionic Gonadotropin - therapeutic use
Clomiphene - therapeutic use
Endocrinology
Endometrium - drug effects
Estradiol - blood
Female
Fertility Agents, Female - therapeutic use
Gynecology
Human Genetics
Humans
India
Infertility, Female - drug therapy
Medicine
Medicine & Public Health
Nitriles - therapeutic use
Obstetrics/Perinatology/Midwifery
Ovarian Follicle - drug effects
Ovulation Induction
Polycystic Ovary Syndrome - drug therapy
Pregnancy
Pregnancy Rate
Reproductive Medicine
Treatment Outcome
Triazoles - therapeutic use
Young Adult
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Summary:Objectives The objective of this study was to compare the efficacy of letrozole versus clomiphene citrate as an ovulation induction drug in polycystic ovarian syndrome (PCOS) patients of Indian origin. Method One hundred and forty seven infertile PCOS patients were randomly given letrozole (2.5 mg) ( n  = 69) or clomiphene (100 mg) ( n  = 78) from day 3 to day 7 of menstrual cycle, followed-up with transvaginal serial folliculometry from day 9. 10,000 IU of human chorionic gonadotropin (hCG) was administered when at least 1 ovarian follicle was ≥ 18 mm in size. Results The pertinent results of the study are as follows: on the day of hCG injection, mean E2 level was significantly higher in the clomphene citrate group (817 ± 286.70 pg/ml) in comparison with letrozole group (444.03 ± 85.42 pg/ml). Mean endometrial development was 8.72 ± 1.41 mm in the letrozole and 8.78 ± 1.16 mm in the clomiphene group ( P  = 0.004). Conclusion Letrozole has beneficial effect on endometrium, thereby potentially increasing pregnancy rates after successful ovulation induction in women with PCOS.
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-011-2091-7