Management of multidrug-resistant viruses in the immunocompromised host

Summary Multidrug‐resistant viruses remain a clinically challenging complication in the immunocompromised host. This review discusses mechanisms of viral resistance and treatment options in this context with particular emphasis on the immunocompromised haematology patient. We also outline some of th...

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Bibliographic Details
Published in:British journal of haematology 2012-03, Vol.156 (5), p.559-572
Main Authors: Sellar, Rob S., Peggs, Karl S.
Format: Article
Language:English
Subjects:
allogeneic transplant
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
Biological and medical sciences
cytomegalovirus
Cytomegalovirus - drug effects
Cytomegalovirus Infections - drug therapy
Cytomegalovirus Infections - immunology
Drug Resistance, Multiple, Viral - drug effects
Drug Resistance, Multiple, Viral - immunology
Hematologic and hematopoietic diseases
Herpes Simplex - drug therapy
Herpes Simplex - immunology
Herpes Zoster - drug therapy
Herpes Zoster - immunology
Herpesviridae - drug effects
herpesvirus
Herpesvirus 3, Human - drug effects
Humans
Immunocompromised Host
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Medical sciences
multidrug-resistant virus
Simplexvirus - drug effects
Viral diseases
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Summary:Summary Multidrug‐resistant viruses remain a clinically challenging complication in the immunocompromised host. This review discusses mechanisms of viral resistance and treatment options in this context with particular emphasis on the immunocompromised haematology patient. We also outline some of the newer agents and treatment strategies being developed to treat multidrug‐resistant viruses.
ISSN:0007-1048
1365-2141
DOI:10.1111/j.1365-2141.2011.08988.x