Epidemiological survey of rifampicin resistance in clinic isolates of Brucella melitensis obtained from all regions of Turkey

Abstract The aim of the present study was to assess the antimicrobial susceptibility of Brucella melitensis isolates to rifampicin (RIF) depending on time and regional differences. A total of 94 human Brucella isolates collected in an 8-year period from the beginning of 2002 to the end of 2009 throu...

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Bibliographic Details
Published in:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2012-02, Vol.18 (1), p.41-46
Main Authors: Sayan, Murat, Kılıc, Selcuk, Uyanık, Muhammet Hamidullah
Format: Article
Language:English
Subjects:
Antibiotics, Antitubercular - pharmacology
Antimicrobial agents
Bacterial Typing Techniques
Biovar
Brucella
Brucella melitensis
Brucella melitensis - drug effects
Brucella melitensis - isolation & purification
Brucella melitensis - metabolism
Brucellosis
Brucellosis - epidemiology
Brucellosis - microbiology
Drug Resistance, Bacterial
Geography
Hematology, Oncology and Palliative Medicine
Humans
Infectious Diseases
Medical Microbiology
Medicine
Medicine & Public Health
Microbial sensitivity test
Microbial Sensitivity Tests
Minimum inhibitory concentration
Original Article
Rifampicin
Rifampin
Rifampin - pharmacology
Turkey - epidemiology
Virology
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Summary:Abstract The aim of the present study was to assess the antimicrobial susceptibility of Brucella melitensis isolates to rifampicin (RIF) depending on time and regional differences. A total of 94 human Brucella isolates collected in an 8-year period from the beginning of 2002 to the end of 2009 throughout Turkey were investigated. The isolates were identified at species and biovar levels by conventional methods, and minimum inhibitory concentrations (MIC) of RIF was determined by using the E test method. All isolates were identified as B. melitensis (93 isolates, biovar 3; 1, biovar 1), and MIC50 and MIC90 values of RIF were 1 and 1.5 μg/ml, respectively (MIC range, 0.25–1.5 μg/ml). All isolates were sensitive to RIF except 2 isolates, which had intermediate susceptibility to RIF. These findings indicated that B. melitensis biovar 3 may be the most frequently agent responsible for human brucellosis in Turkey. None of the isolates in our region was resistant to RIF.
ISSN:1341-321X
1437-7780
DOI:10.1007/s10156-011-0281-7