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Epidemiological survey of rifampicin resistance in clinic isolates of Brucella melitensis obtained from all regions of Turkey
Abstract The aim of the present study was to assess the antimicrobial susceptibility of Brucella melitensis isolates to rifampicin (RIF) depending on time and regional differences. A total of 94 human Brucella isolates collected in an 8-year period from the beginning of 2002 to the end of 2009 throu...
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| Published in: | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2012-02, Vol.18 (1), p.41-46 |
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| container_end_page | 46 |
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| container_start_page | 41 |
| container_title | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy |
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| creator | Sayan, Murat Kılıc, Selcuk Uyanık, Muhammet Hamidullah |
| description | Abstract The aim of the present study was to assess the antimicrobial susceptibility of Brucella melitensis isolates to rifampicin (RIF) depending on time and regional differences. A total of 94 human Brucella isolates collected in an 8-year period from the beginning of 2002 to the end of 2009 throughout Turkey were investigated. The isolates were identified at species and biovar levels by conventional methods, and minimum inhibitory concentrations (MIC) of RIF was determined by using the E test method. All isolates were identified as B. melitensis (93 isolates, biovar 3; 1, biovar 1), and MIC50 and MIC90 values of RIF were 1 and 1.5 μg/ml, respectively (MIC range, 0.25–1.5 μg/ml). All isolates were sensitive to RIF except 2 isolates, which had intermediate susceptibility to RIF. These findings indicated that B. melitensis biovar 3 may be the most frequently agent responsible for human brucellosis in Turkey. None of the isolates in our region was resistant to RIF. |
| doi_str_mv | 10.1007/s10156-011-0281-7 |
| format | article |
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A total of 94 human Brucella isolates collected in an 8-year period from the beginning of 2002 to the end of 2009 throughout Turkey were investigated. The isolates were identified at species and biovar levels by conventional methods, and minimum inhibitory concentrations (MIC) of RIF was determined by using the E test method. All isolates were identified as B. melitensis (93 isolates, biovar 3; 1, biovar 1), and MIC50 and MIC90 values of RIF were 1 and 1.5 μg/ml, respectively (MIC range, 0.25–1.5 μg/ml). All isolates were sensitive to RIF except 2 isolates, which had intermediate susceptibility to RIF. These findings indicated that B. melitensis biovar 3 may be the most frequently agent responsible for human brucellosis in Turkey. None of the isolates in our region was resistant to RIF.</description><identifier>ISSN: 1341-321X</identifier><identifier>EISSN: 1437-7780</identifier><identifier>DOI: 10.1007/s10156-011-0281-7</identifier><identifier>PMID: 21826587</identifier><language>eng</language><publisher>Japan: Elsevier Ltd</publisher><subject>Antibiotics, Antitubercular - pharmacology ; Antimicrobial agents ; Bacterial Typing Techniques ; Biovar ; Brucella ; Brucella melitensis ; Brucella melitensis - drug effects ; Brucella melitensis - isolation & purification ; Brucella melitensis - metabolism ; Brucellosis ; Brucellosis - epidemiology ; Brucellosis - microbiology ; Drug Resistance, Bacterial ; Geography ; Hematology, Oncology and Palliative Medicine ; Humans ; Infectious Diseases ; Medical Microbiology ; Medicine ; Medicine & Public Health ; Microbial sensitivity test ; Microbial Sensitivity Tests ; Minimum inhibitory concentration ; Original Article ; Rifampicin ; Rifampin ; Rifampin - pharmacology ; Turkey - epidemiology ; Virology</subject><ispartof>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2012-02, Vol.18 (1), p.41-46</ispartof><rights>Japanese Society of Chemotherapy and the Japanese Association for Infectious Diseases</rights><rights>2012 Japanese Society of Chemotherapy and the Japanese Association for Infectious Diseases</rights><rights>Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-ace665512376859534ee2fe8bf6ae54064bd732543815098d2d3054a6e18d97e3</citedby><cites>FETCH-LOGICAL-c536t-ace665512376859534ee2fe8bf6ae54064bd732543815098d2d3054a6e18d97e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21826587$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sayan, Murat</creatorcontrib><creatorcontrib>Kılıc, Selcuk</creatorcontrib><creatorcontrib>Uyanık, Muhammet Hamidullah</creatorcontrib><title>Epidemiological survey of rifampicin resistance in clinic isolates of Brucella melitensis obtained from all regions of Turkey</title><title>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</title><addtitle>J Infect Chemother</addtitle><addtitle>J Infect Chemother</addtitle><description>Abstract The aim of the present study was to assess the antimicrobial susceptibility of Brucella melitensis isolates to rifampicin (RIF) depending on time and regional differences. A total of 94 human Brucella isolates collected in an 8-year period from the beginning of 2002 to the end of 2009 throughout Turkey were investigated. The isolates were identified at species and biovar levels by conventional methods, and minimum inhibitory concentrations (MIC) of RIF was determined by using the E test method. All isolates were identified as B. melitensis (93 isolates, biovar 3; 1, biovar 1), and MIC50 and MIC90 values of RIF were 1 and 1.5 μg/ml, respectively (MIC range, 0.25–1.5 μg/ml). All isolates were sensitive to RIF except 2 isolates, which had intermediate susceptibility to RIF. These findings indicated that B. melitensis biovar 3 may be the most frequently agent responsible for human brucellosis in Turkey. None of the isolates in our region was resistant to RIF.</description><subject>Antibiotics, Antitubercular - pharmacology</subject><subject>Antimicrobial agents</subject><subject>Bacterial Typing Techniques</subject><subject>Biovar</subject><subject>Brucella</subject><subject>Brucella melitensis</subject><subject>Brucella melitensis - drug effects</subject><subject>Brucella melitensis - isolation & purification</subject><subject>Brucella melitensis - metabolism</subject><subject>Brucellosis</subject><subject>Brucellosis - epidemiology</subject><subject>Brucellosis - microbiology</subject><subject>Drug Resistance, Bacterial</subject><subject>Geography</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Infectious Diseases</subject><subject>Medical Microbiology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microbial sensitivity test</subject><subject>Microbial Sensitivity Tests</subject><subject>Minimum inhibitory concentration</subject><subject>Original Article</subject><subject>Rifampicin</subject><subject>Rifampin</subject><subject>Rifampin - pharmacology</subject><subject>Turkey - epidemiology</subject><subject>Virology</subject><issn>1341-321X</issn><issn>1437-7780</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kk9rFDEYh4Motl39AF4kN72M5n8yCEItrQoFD1bwFrKZd5bUzGRNZgp78Lub6VQFD3sIScjzexPeJwi9oOQNJUS_LZRQqRpCaUOYoY1-hE6p4LrR2pDHdc0FbTij30_QWSm3hFAtjXmKThg1TEmjT9Gvy33oYAgppl3wLuIy5zs44NTjHHo37IMPI85QQpnc6AHXnY9hDB6HkqKboCzshzx7iNHhAWKYYKw4TtvJhRE63Oc0YBdjLbMLabwP3Mz5BxyeoSe9iwWeP8wb9O3q8ubiU3P95ePni_PrxkuupsZ5UEpKyrhWRraSCwDWg9n2yoEURIltpzmTghsqSWs61nEihVNATddq4Bv0aq27z-nnDGWyQyj3Dx4hzcW2rPaRqzo26PVRkhJGDG-FWFC6oj6nUjL0dp_D4PKhQnbxY1c_tvqxix-ra-blQ_l5O0D3N_FHSAXYCpR6NO4g29s057E252jVd2sIag_vQg0VH6Da6kIGP9kuhaPp9_-lV8EuVkNQ_t1vC7PEfl1-1fKpKNOEC035bwSExAY</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Sayan, Murat</creator><creator>Kılıc, Selcuk</creator><creator>Uyanık, Muhammet Hamidullah</creator><general>Elsevier Ltd</general><general>Springer Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20120201</creationdate><title>Epidemiological survey of rifampicin resistance in clinic isolates of Brucella melitensis obtained from all regions of Turkey</title><author>Sayan, Murat ; Kılıc, Selcuk ; Uyanık, Muhammet Hamidullah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-ace665512376859534ee2fe8bf6ae54064bd732543815098d2d3054a6e18d97e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Antibiotics, Antitubercular - pharmacology</topic><topic>Antimicrobial agents</topic><topic>Bacterial Typing Techniques</topic><topic>Biovar</topic><topic>Brucella</topic><topic>Brucella melitensis</topic><topic>Brucella melitensis - drug effects</topic><topic>Brucella melitensis - isolation & purification</topic><topic>Brucella melitensis - metabolism</topic><topic>Brucellosis</topic><topic>Brucellosis - epidemiology</topic><topic>Brucellosis - microbiology</topic><topic>Drug Resistance, Bacterial</topic><topic>Geography</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Infectious Diseases</topic><topic>Medical Microbiology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microbial sensitivity test</topic><topic>Microbial Sensitivity Tests</topic><topic>Minimum inhibitory concentration</topic><topic>Original Article</topic><topic>Rifampicin</topic><topic>Rifampin</topic><topic>Rifampin - pharmacology</topic><topic>Turkey - epidemiology</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sayan, Murat</creatorcontrib><creatorcontrib>Kılıc, Selcuk</creatorcontrib><creatorcontrib>Uyanık, Muhammet Hamidullah</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sayan, Murat</au><au>Kılıc, Selcuk</au><au>Uyanık, Muhammet Hamidullah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiological survey of rifampicin resistance in clinic isolates of Brucella melitensis obtained from all regions of Turkey</atitle><jtitle>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</jtitle><stitle>J Infect Chemother</stitle><addtitle>J Infect Chemother</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>18</volume><issue>1</issue><spage>41</spage><epage>46</epage><pages>41-46</pages><issn>1341-321X</issn><eissn>1437-7780</eissn><abstract>Abstract The aim of the present study was to assess the antimicrobial susceptibility of Brucella melitensis isolates to rifampicin (RIF) depending on time and regional differences. A total of 94 human Brucella isolates collected in an 8-year period from the beginning of 2002 to the end of 2009 throughout Turkey were investigated. The isolates were identified at species and biovar levels by conventional methods, and minimum inhibitory concentrations (MIC) of RIF was determined by using the E test method. All isolates were identified as B. melitensis (93 isolates, biovar 3; 1, biovar 1), and MIC50 and MIC90 values of RIF were 1 and 1.5 μg/ml, respectively (MIC range, 0.25–1.5 μg/ml). All isolates were sensitive to RIF except 2 isolates, which had intermediate susceptibility to RIF. These findings indicated that B. melitensis biovar 3 may be the most frequently agent responsible for human brucellosis in Turkey. None of the isolates in our region was resistant to RIF.</abstract><cop>Japan</cop><pub>Elsevier Ltd</pub><pmid>21826587</pmid><doi>10.1007/s10156-011-0281-7</doi><tpages>6</tpages></addata></record> |
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| subjects | Antibiotics, Antitubercular - pharmacology Antimicrobial agents Bacterial Typing Techniques Biovar Brucella Brucella melitensis Brucella melitensis - drug effects Brucella melitensis - isolation & purification Brucella melitensis - metabolism Brucellosis Brucellosis - epidemiology Brucellosis - microbiology Drug Resistance, Bacterial Geography Hematology, Oncology and Palliative Medicine Humans Infectious Diseases Medical Microbiology Medicine Medicine & Public Health Microbial sensitivity test Microbial Sensitivity Tests Minimum inhibitory concentration Original Article Rifampicin Rifampin Rifampin - pharmacology Turkey - epidemiology Virology |
| title | Epidemiological survey of rifampicin resistance in clinic isolates of Brucella melitensis obtained from all regions of Turkey |
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