Anti-inflammatory effect of quetiapine on collagen-induced arthritis of mouse

• Published in: European journal of pharmacology 2012-03, Vol.678 (1-3), p.55-60
• Main Authors: Kim, Hyeongseok, Bang, Jihye, Chang, Hyuk Won, Kim, Jin Young, Park, Keon Uk, Kim, Sang-Hyon, Lee, Kyung-Jae, Cho, Chul-Hyun, Hwang, Ilseon, Park, Sung Dong, Ha, Eunyoung, Jung, Sung-Won
• Format: Article
• Language: English
• Subjects: Animals; anti-inflammatory activity; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Antibodies - blood; antidepressants; arthritis; Arthritis, Experimental - blood; Arthritis, Experimental - diagnostic imaging; Arthritis, Experimental - drug therapy; Arthritis, Experimental - pathology; Arthritis, Rheumatoid - drug therapy; Body Weight - drug effects; Bone and Bones - diagnostic imaging; Bone and Bones - drug effects; Bone and Bones - pathology; cartilage; Cartilage - diagnostic imaging; Cartilage - drug effects; Cartilage - pathology; collagen; Dibenzothiazepines - pharmacology; Dibenzothiazepines - therapeutic use; Dinoprostone - blood; IL-17 (interleukin-17); IL-6 (interleukin-6); Inflammation; Interleukin-17 - blood; interleukin-6; Interleukin-6 - blood; Intramolecular Oxidoreductases - biosynthesis; Male; Mice; Mice, Inbred DBA; Prostaglandin-E Synthases; prostaglandins; Quetiapine; Quetiapine Fumarate; Radiography; Rheumatoid arthritis; Tumor Necrosis Factor-alpha - blood; weight gain
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/j.ejphar.2011.12.017

Quetiapine is an atypical antipsychotic and has also been used in the treatment of depression. Since anti-inflammatory effects of antidepressants are well established, we hypothesized that quetiapine may also exert anti-inflammatory effects. Thus this study was designed to examine the anti-inflammatory effect of quetiapine in murine collagen-induced arthritis. Mice were immunized with collagen type II for the induction of arthritis and treated with quetiapine (10mg/kg) daily for 2weeks. Mice were divided into 3 groups: control, CIA, and CIA+quetiapine treatment. Arthritic index and paw thickness were used to compare severity of arthritis. In additions, radiological and histological assessments were employed. Anti-type II collagen-specific antibody, interleukin-6 (IL-6), interleukin-17 (IL-17), and prostaglandin E2 (PGE2) were evaluated at the end of the treatment period. Both arthritic index and paw thickness were markedly improved in CIA+quetiapine treatment group compared with those in CIA groups (arthritic index; P