Oesophageal atresia: prevalence, prenatal diagnosis and associated anomalies in 23 European regions

Objective To describe prevalence, prenatal diagnosis and epidemiological data on oesophageal atresia from 23 well-defined European regions and compare the prevalence between these regions. Design Population-based study using data from a large European database for surveillance of congenital anomalie...

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Bibliographic Details
Published in:Archives of disease in childhood 2012-03, Vol.97 (3), p.227-232
Main Authors: Pedersen, Rikke Neess, Calzolari, Elisa, Husby, Steffen, Garne, Ester
Format: Article
Language:English
Subjects:
Abnormalities, Multiple - diagnosis
Abnormalities, Multiple - epidemiology
Abortion, Induced - utilization
Analysis
Associations
Biological and medical sciences
Birth defects
Births
Congenital defects
Congenital Impairments
Death
Diagnosis
Down Syndrome
Environmental Influences
Esophageal Atresia - diagnosis
Esophageal Atresia - epidemiology
Esophagus
Europe - epidemiology
Female
Fetal Death
Fetal Diseases - diagnosis
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Gestational Age
Humans
Infant, Newborn
International Cooperation
Male
Malformations
Medical prognosis
Medical sciences
Miscellaneous
Patients
Population studies
Pregnancy
Prenatal diagnosis
Prenatal Diagnosis - utilization
Prevalence
Prevention and actions
Prognosis
Public health. Hygiene
Public health. Hygiene-occupational medicine
Registries
Sex Distribution
Statistical Analysis
Surgery
Tracheoesophageal Fistula - epidemiology
Young Children
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Summary:Objective To describe prevalence, prenatal diagnosis and epidemiological data on oesophageal atresia from 23 well-defined European regions and compare the prevalence between these regions. Design Population-based study using data from a large European database for surveillance of congenital anomalies (EUROCAT) for two decades (1987–2006). Settings Twenty-three participating registries based on multiple sources of information including information about live births, fetal deaths with gestational age ≥20 weeks and terminations of pregnancy. Patients 1222 cases of oesophageal atresia in a population of 5 019 804 births. Results The overall prevalence was 2.43 cases per 10 000 births (95% CI 2.30 to 2.57). There were regional differences in prevalence ranging from 1.27 to 4.55. Prenatal detection rates varied by registry from >50% of cases to
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2011-300597