HLA class II restriction of HIV-1 clade-specific neutralizing antibody responses in ethnic Thai recipients of the RV144 prime-boost vaccine combination of ALVAC-HIV and AIDSVAX® B/E

Immune responses to vaccines may be influenced or associated with allelic variants of host genes such as those encoding human leucocyte antigens (HLA). We have molecularly determined the HLA class II DR and DQ gene, allele and haploype profiles in HIV-1 negative ethnic Thai recipients of an HIV-1 pr...

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Bibliographic Details
Published in:Vaccine 2012-01, Vol.30 (5), p.832-836
Main Authors: Paris, Robert, Bejrachandra, Sasitorn, Thongcharoen, Prasert, Nitayaphan, Sorachai, Pitisuttithum, Punnee, Sambor, Anna, Gurunathan, Sanjay, Francis, Donald, Ratto-Kim, Silvia, Karnasuta, Chitraporn, de Souza, Mark S, Polonis, Victoria R, Brown, Arthur E, Kim, Jerome H, Stephens, Henry A
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
AIDS Vaccines - administration & dosage
AIDS Vaccines - immunology
Alleles
Allergy and Immunology
Antibodies, Neutralizing - blood
Antigens
Chromosomes
Confidence intervals
Gene loci
Genotype
Haplotypes
Histocompatibility Antigens Class II - genetics
Histocompatibility Antigens Class II - immunology
HIV Antibodies - blood
HIV-1
HLA
Human Experimentation
Human immunodeficiency virus 1
Humans
immune response
MHC
neutralizing antibodies
Neutralizing antibody
RV135
RV144
Southeast Asians
Thailand
Vaccine
Vaccines
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Summary:Immune responses to vaccines may be influenced or associated with allelic variants of host genes such as those encoding human leucocyte antigens (HLA). We have molecularly determined the HLA class II DR and DQ gene, allele and haploype profiles in HIV-1 negative ethnic Thai recipients of an HIV-1 prime boost vaccine regimen, designed to induce neutralizing antibody (NAb) responses to HIV-1 CRF01_AE. Non-response to vaccine associated with DRB1*11 (3/32 responders vs. 7/13 non-responders, pc=0.027) and DRB1*16:02 (0/32 responders vs. 4/13 non-responders, pc=0.078) alleles. Furthermore, vaccine recipients with HLA-DQ heterodimers encoded by DQA1*05:01 and DQB1*03:01 alleles, were much less likely to produce NAb (p=0.009). These data suggest that the lack of response to a vaccine designed to induce clade-specific NAb to HIV-1 is associated with the presence of certain HLA class II alleles and heterodimers in some Southeast Asians.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.11.002