Transcription Regulation System Mediated by Mechanical Operation of a DNA Nanostructure

A transcription regulation system initiated by DNA nanostructure changes was designed and constructed. Using the toehold system, specific DNA strands induced the opening of the tubular structure. A transcription product from the purified tube-attached dsDNA template was observed by addition of DNA s...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2012-02, Vol.134 (6), p.2852-2855
Main Authors: Endo, Masayuki, Miyazaki, Ryoji, Emura, Tomoko, Hidaka, Kumi, Sugiyama, Hiroshi
Format: Article
Language:English
Subjects:
Base Sequence
Biotin - chemistry
Disulfides
DNA - chemistry
DNA-Directed RNA Polymerases - chemistry
Gene Expression Regulation
Imaging, Three-Dimensional
Molecular Sequence Data
Nanocomposites
Nanotechnology - methods
Nucleic Acid Conformation
Stress, Mechanical
Transcription, Genetic
Viral Proteins - chemistry
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Summary:A transcription regulation system initiated by DNA nanostructure changes was designed and constructed. Using the toehold system, specific DNA strands induced the opening of the tubular structure. A transcription product from the purified tube-attached dsDNA template was observed by addition of DNA strands that were specific for opening the tubular structure.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja2074856