Developments in Ultra-Fast Temperature Programming with Silicon Micromachined Gas Chromatography: Performance and Limitations

Various commercially available ultra-fast temperature programming approaches were integrated to silicon micromachined GC (micro-GC) for performance improvement assessment. The combined technique of micro-GC and ultra-fast temperature programming up to a rate of 6°C/second yielded an extended analysi...

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Bibliographic Details
Published in:Journal of chromatographic science 2012-03, Vol.50 (3), p.245-252
Main Authors: Luong, Jim, Cai, Huamin, Gras, Ronda, Curvers, Jos
Format: Article
Language:English
Subjects:
Analytical chemistry
Assessments
Chemistry
Chromatographic methods and physical methods associated with chromatography
Exact sciences and technology
Gas chromatographic methods
Indexing in process
Micromachining
Micromechanics
Performance enhancement
Programming
Reproducibility
Silicon
Standard deviation
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Summary:Various commercially available ultra-fast temperature programming approaches were integrated to silicon micromachined GC (micro-GC) for performance improvement assessment. The combined technique of micro-GC and ultra-fast temperature programming up to a rate of 6°C/second yielded an extended analysis range to undecane (nC11), improved signal detectability by at least a factor of three for the solutes studied with respectable one day reproducibility of less than 1% relative standard deviation in retention time (n = 20). Through careful control of various variables affecting retention time, performance improvements can be extended further. The various effects temperature programming has on the stability of thermal conductivity detector as well as criteria that need to be met for the successful implementation of ultra-fast temperature programming in micro-GC are presented.
ISSN:0021-9665
1945-239X
DOI:10.1093/chromsci/bmr052