Polymorphism 1558 C > T in the aromatase gene (CYP19A1) in low-grade endometrial stromal sarcoma

Low-grade endometrial stromal sacomas (ESS) are estrogen-sensitive tumors. Polymorphic variation in the CYP19 gene can affect estrogen synthesis by increasing aromatase activity resulting in elevated levels of estrone and estradiol. We examined the polymorphism 1558 C > T in he aromatase gene (CY...

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Bibliographic Details
Published in:European journal of gynaecological oncology 2011, Vol.32 (6), p.626-627
Main Authors: Reich, O, Regauer, S, Tempfer, C, Schneeberger, C, Huber, J
Format: Article
Language:English
Subjects:
Aromatase - genetics
Endometrial Neoplasms - genetics
Endometrial Neoplasms - pathology
Female
Genotype
Humans
Neoplasm Grading
Polymorphism, Single Nucleotide
Sarcoma, Endometrial Stromal - genetics
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Summary:Low-grade endometrial stromal sacomas (ESS) are estrogen-sensitive tumors. Polymorphic variation in the CYP19 gene can affect estrogen synthesis by increasing aromatase activity resulting in elevated levels of estrone and estradiol. We examined the polymorphism 1558 C > T in he aromatase gene (CYP19A1) in a series of 20 low-grade endometrial stromal sarcomas. Archival formalinfixed and paraffin-embedded material was analyzed with a fast real-time PCR system. The homozygous C/T- and the homozygous mutant T/T-genotypes were detected in 10/20 (50%) and 7/20 (35%) samples, respectively. Polymorphism 1558 C > T in the aromatase gene may represent a high-risk allele with increased local estrogen levels.
ISSN:0392-2936