Hepatitis B virus infection and fatty liver in the general population

Background & Aims In animal studies, expression of hepatitis B virus (HBV) proteins causes hepatic steatosis. We aimed to study the prevalence of fatty liver in people with and without HBV infection in the general population. Methods We performed a cross-sectional population study in Hong Kong C...

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Bibliographic Details
Published in:Journal of hepatology 2012-03, Vol.56 (3), p.533-540
Main Authors: Wong, Vincent Wai-Sun, Wong, Grace Lai-Hung, Chu, Winnie Chiu-Wing, Chim, Angel Mei-Ling, Ong, Arlinking, Yeung, David Ka-Wai, Yiu, Karen Kar-Lum, Chu, Shirley Ho-Ting, Chan, Hoi-Yun, Woo, Jean, Chan, Francis Ka-Leung, Chan, Henry Lik-Yuen
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Cross-Sectional Studies
Cross-sectional study
Diabetes mellitus
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - metabolism
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Fatty Liver - ethnology
Fatty Liver - metabolism
Female
Gastroenterology and Hepatology
Gastroenterology. Liver. Pancreas. Abdomen
Hepatitis B, Chronic - epidemiology
Hepatitis B, Chronic - metabolism
Hong Kong - epidemiology
Human viral diseases
Humans
Hypertriglyceridemia
Hypertriglyceridemia - epidemiology
Hypertriglyceridemia - metabolism
Infectious diseases
Lipid Metabolism - physiology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Metabolic Syndrome - epidemiology
Metabolic Syndrome - metabolism
Middle Aged
Nonalcoholic fatty liver disease
Nonalcoholic steatohepatitis
Obesity
Other diseases. Semiology
Prevalence
Risk Factors
Viral diseases
Viral hepatitis
Young Adult
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Summary:Background & Aims In animal studies, expression of hepatitis B virus (HBV) proteins causes hepatic steatosis. We aimed to study the prevalence of fatty liver in people with and without HBV infection in the general population. Methods We performed a cross-sectional population study in Hong Kong Chinese. Intrahepatic triglyceride content (IHTG) was measured by proton-magnetic resonance spectroscopy. Results One thousand and thirteen subjects (91 HBV patients and 922 controls) were recruited. The median IHTG was 1.3% (0.2–33.3) in HBV patients and 2.1% (0–44.2) in controls ( p
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2011.09.013