Evaluation of the Nerve Fiber Layer and Macula in the Eyes of Healthy Children Using Spectral-Domain Optical Coherence Tomography

Purpose To determine the normative values of the peripapillary retinal nerve fiber layer (RNFL), macular thickness, and macular volume in healthy children using spectral-domain optical coherence tomography (SD-OCT) and analyze the correlation of such values with age, refraction error, and biometric...

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Bibliographic Details
Published in:American journal of ophthalmology 2012-03, Vol.153 (3), p.552-559.e1
Main Authors: Turk, Adem, Ceylan, Osman Melih, Arici, Ceyhun, Keskin, Soner, Erdurman, Cuneyt, Durukan, Ali Hakan, Mutlu, Fatih Mehmet, Altinsoy, Halil Ibrahim
Format: Article
Language:English
Subjects:
Adolescent
Aging - physiology
Axons
Biological and medical sciences
Biometry
Child
Eyes & eyesight
Female
Glaucoma
Humans
Macula Lutea - anatomy & histology
Male
Medical sciences
Miscellaneous
Ophthalmology
Optic Disk - anatomy & histology
Optic nerve
Optics
Pediatrics
Reference Values
Refractive Errors - physiopathology
Reproducibility of Results
Retinal Ganglion Cells - cytology
Studies
Tomography, Optical Coherence
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Summary:Purpose To determine the normative values of the peripapillary retinal nerve fiber layer (RNFL), macular thickness, and macular volume in healthy children using spectral-domain optical coherence tomography (SD-OCT) and analyze the correlation of such values with age, refraction error, and biometric measurements. Design Observational case series. Methods This institutional study involved 107 eyes from 107 healthy pediatric patients (54 female, 53 male) with ages between 6 and 16 years. After the biometric measurements and refractive error values (in spherical equivalent) of the cases were obtained, the peripapillary RNFL, macular thickness, and macular volume values were calculated using the Spectralis OCT device. Results Among the study group, with an average age of 10.46 ± 2.94 years, the average axial length (AL) was 23.33 ± 0.89 mm; the average spherical equivalent (SE) value was −0.27 ± 0.99 diopter. The average peripapillary RNFL thickness was 106.45 ± 9.41 μm; the average macular thickness was 326.44 ± 14.17 μm; and the average macular volume was 0.257 ± 0.011 mm3 . The aforementioned OCT measurements were not significantly correlated with age, SE, or AL values ( P > .05 for all). Conclusions This study reports SD-OCT findings among healthy pediatric cases. SD-OCT can be reliably used for pediatric patients because of its short exposure time and high degree of image resolution.
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2011.08.026