Targeting the Assembly of Bacterial Cell Division Protein FtsZ with Small Molecules

FtsZ is the key protein of bacterial cell division and an emergent target for new antibiotics. It is a filament-forming GTPase and a structural homologue of eukaryotic tubulin. A number of FtsZ-interacting compounds have been reported, some of which have powerful antibacterial activity. Here we revi...

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Bibliographic Details
Published in:ACS chemical biology 2012-02, Vol.7 (2), p.269-277
Main Authors: Schaffner-Barbero, Claudia, Martín-Fontecha, Mar, Chacón, Pablo, Andreu, José M
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Bacteria - chemistry
Bacteria - drug effects
Bacteria - metabolism
Bacterial Infections - drug therapy
Bacterial Proteins - antagonists & inhibitors
Bacterial Proteins - chemistry
Bacterial Proteins - metabolism
Cytoskeletal Proteins - antagonists & inhibitors
Cytoskeletal Proteins - chemistry
Cytoskeletal Proteins - metabolism
Humans
Models, Molecular
Small Molecule Libraries - chemistry
Small Molecule Libraries - pharmacology
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Summary:FtsZ is the key protein of bacterial cell division and an emergent target for new antibiotics. It is a filament-forming GTPase and a structural homologue of eukaryotic tubulin. A number of FtsZ-interacting compounds have been reported, some of which have powerful antibacterial activity. Here we review recent advances and new approaches in modulating FtsZ assembly with small molecules. This includes analyzing their chemical features, binding sites, mechanisms of action, the methods employed, and computational insights, aimed at a better understanding of their molecular recognition by FtsZ and at rational antibiotic design.
ISSN:1554-8929
1554-8937
DOI:10.1021/cb2003626