RNA-binding Sm-like proteins of bacteria and archaea. Similarity and difference in structure and function

RNA-binding proteins play a significant role in many processes of RNA metabolism, such as splicing and processing, regulation of DNA transcription and RNA translation, etc. Among the great number of RNA-binding proteins, so-called RNA-chaperones occupy an individual niche; they were named for their...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2011-12, Vol.76 (13), p.1434-1449
Main Authors: Murina, V. N., Nikulin, A. D.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino acids
Analysis
Archaea
Archaeal Proteins - chemistry
Archaeal Proteins - genetics
Archaeal Proteins - physiology
Bacteria
Bacterial Proteins - chemistry
Bacterial Proteins - genetics
Bacterial Proteins - physiology
Binding Sites
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Conserved Sequence
DNA
Genetic transcription
Genetic translation
Host Factor 1 Protein - chemistry
Host Factor 1 Protein - genetics
Host Factor 1 Protein - physiology
Life Sciences
Microbiology
Molecular Sequence Data
Protein Conformation
Proteins
Review
Ribonucleic acid
RNA
RNA Stability
snRNP Core Proteins - chemistry
snRNP Core Proteins - physiology
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Summary:RNA-binding proteins play a significant role in many processes of RNA metabolism, such as splicing and processing, regulation of DNA transcription and RNA translation, etc. Among the great number of RNA-binding proteins, so-called RNA-chaperones occupy an individual niche; they were named for their ability to assist RNA molecules to gain their accurate native spatial structure. When binding with RNAs, they possess the capability of altering (melting) their secondary structure, thus providing a possibility for formation of necessary intramolecular contacts between individual RNA sites for proper folding. These proteins also have an additional helper function in RNA-RNA and RNA-protein interactions. Members of such class of the RNA-binding protein family are Sm and Sm-like proteins (Sm-Like, LSm). The presence of these proteins in bacteria, archaea, and eukaryotes emphasizes their biological significance. These proteins are now attractive for researchers because of their implication in many processes associated with RNAs in bacterial and archaeal cells. This review is focused on a comparison of architecture of bacterial and archaeal LSm proteins and their interaction with different RNA molecules.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297911130050