5S rRNA and ribosome

5S rRNA is an integral component of the ribosome of all living organisms. It is known that the ribosome without 5S rRNA is functionally inactive. However, the question about the specific role of this RNA in functioning of the translation apparatus is still open. This review presents a brief history...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2011-12, Vol.76 (13), p.1450-1464
Main Author: Gongadze, G. M.
Format: Article
Language:English
Subjects:
Bacteria
Bacterial Proteins - chemistry
Bacterial Proteins - metabolism
Bacterial Proteins - physiology
Base Sequence
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Life Sciences
Microbiology
Molecular Sequence Data
Nucleic Acid Conformation
Organisms
Protein Biosynthesis
Protein Conformation
Review
Ribonucleic acid
Ribosomal Proteins - chemistry
Ribosomal Proteins - metabolism
Ribosomal Proteins - physiology
Ribosomes - chemistry
Ribosomes - metabolism
Ribosomes - physiology
RNA
RNA, Bacterial - chemistry
RNA, Bacterial - metabolism
RNA, Bacterial - physiology
RNA, Ribosomal, 5S - chemistry
RNA, Ribosomal, 5S - metabolism
RNA, Ribosomal, 5S - physiology
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Summary:5S rRNA is an integral component of the ribosome of all living organisms. It is known that the ribosome without 5S rRNA is functionally inactive. However, the question about the specific role of this RNA in functioning of the translation apparatus is still open. This review presents a brief history of the discovery of 5S rRNA and studies of its origin and localization in the ribosome. The previously expressed hypotheses about the role of this RNA in the functioning of the ribosome are discussed considering the unique location of 5S rRNA in the ribosome and its intermolecular contacts. Based on analysis of the current data on ribosome structure and its functional complexes, the role of 5S rRNA as an intermediary between ribosome functional domains is discussed.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297911130062