Morphological features of mutant rat, IS-Tlk/Kyo, fetuses with caudal vertebral anomalies

ABSTRACT IS‐Tlk/Kyo, a rat mutant strain derived from IS/Kyo strain, exhibits a kinked and/or short tail, in addition to a congenital anomaly of the lumbar vertebrae that is a hallmark of IS/Kyo rats. Homozygotes (Tlk/Tlk) of Tlk dominant gene are known to die during embryonic development. The prese...

Full description

Saved in:
Bibliographic Details
Published in:Congenital anomalies 2012-03, Vol.52 (1), p.42-47
Main Authors: Takano, Masao, Katsumata, Yoshihiro, Ogawa, Junko, Ebata, Tomonori, Urasoko, Yoshinaka, Asano, Yuzo, Serikawa, Tadao, Kuramoto, Takashi
Format: Article
Language:English
Subjects:
Animals
Body Weight
Crosses, Genetic
Feeding Behavior
Female
Genes, Dominant
Heterozygote
Homozygote
IS rat
lumbar vertebral anomaly
Male
Models, Genetic
Mutation
Rats
Rats, Mutant Strains
Spine - abnormalities
Time Factors
Tlk gene
ventral septal defect
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT IS‐Tlk/Kyo, a rat mutant strain derived from IS/Kyo strain, exhibits a kinked and/or short tail, in addition to a congenital anomaly of the lumbar vertebrae that is a hallmark of IS/Kyo rats. Homozygotes (Tlk/Tlk) of Tlk dominant gene are known to die during embryonic development. The present report deals with the morphological features of heterozygous IS‐Tlk/Kyo rat fetuses in comparison with those of IS/Kyo rat fetuses. One of the morphological features was a high incidence of tail vertebral anomalies in IS‐Tlk rats (81.6% versus 0% in IS/Kyo rats). Significantly low values in number of live fetuses and ossified 5th sternebra and sacral and caudal vertebrae were observed in IS‐Tlk/Kyo rats compared with those in IS/Kyo rats as well as a low incidence of fetuses with ventral septal defects in IS‐Tlk/Kyo (0% versus 54.4% in IS rats). These results suggest that the Tlk gene may be involved in the formation of the vertebral centra and the ventral septum when it expresses on the genetic background of the IS rat.
ISSN:0914-3505
1741-4520
DOI:10.1111/j.1741-4520.2011.00348.x